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20 Cards in this Set
- Front
- Back
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Pharmacology
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The study of drugs in its broadest sense, including interactions between drugs and body constituents at any level of organization.
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Pharmacodynamics
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What the drug does to the body;includes mechanisms of action of drugs at physiological,biochemical,and molecular levels.
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Pharmacokinetics
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What the body does to the drug;how drug concentrations in body fluids and tissues vary with time and intensity of response.
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Pharmacogenetics
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The relationship of genetic factorsto variations in drug responsiveness.
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Receptor
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Specific macromolecule that is the target for drug binding; initial "site of action" of a drug.
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Therapeutic index aka "margin of safety"
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Ratio between the dose of drug causing undesirable effects
and the dose causing the desired therapeutic response. |
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Toxicology
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Study of poisons, their effects, their antidotes, and drug overdoses.
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Proprietary name
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Brand or trade name of a drug that is the patented property of the drug manufacturer; drugs of identical composition may have many different proprietary names
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Pharmacologic antagonist
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A drug that binds to its receptor without activating it
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Physiologic antagonist
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A drug that binds to a different receptor causing an effect that counteracts the effects of another agonist
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Chemical antagonist
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A drug that binds another drug and prevents the bound drug’s pharmacologic effect
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Irreversible antagonist
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A pharmacologic antagonist that cannot be overcome by
increasing the concentration of another agonist |
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Competitive antagonist
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A pharmacologic antagonist that can be overcome by increasing the concentration of another agonist
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Agonist
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a drug that activates its receptor upon binding
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Effector
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component of the biologic system that accomplishes the biologic effect after being activated by the receptor; often a channel or enzyme.
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Partial agonist
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a drug that binds to its receptor but produces a smaller effect at full dosage than a full agonist
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Quantal dose response curve
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a graph of the fraction of its population that shows a specified response to increasing doses of a drug
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Potency
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the dose or concentration required to bring about 50% of the drug's maximum effect
Spare receptors receptors that do not have to bind drug in order for the maximum effect to be produced |
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Efficacy
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maximum effect a drug can bring out regardless of does
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Inert binding site
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component of the biologic system to which a drug binds without changing any function
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