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20 Cards in this Set

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Pharmacology
The study of drugs in its broadest sense, including interactions between drugs and body constituents at any level of organization.
Pharmacodynamics
What the drug does to the body;includes mechanisms of action of drugs at physiological,biochemical,and molecular levels.
Pharmacokinetics
What the body does to the drug;how drug concentrations in body fluids and tissues vary with time and intensity of response.
Pharmacogenetics
The relationship of genetic factorsto variations in drug responsiveness.
Receptor
Specific macromolecule that is the target for drug binding; initial "site of action" of a drug.
Therapeutic index aka "margin of safety"
Ratio between the dose of drug causing undesirable effects
and the dose causing the desired therapeutic response.
Toxicology
Study of poisons, their effects, their antidotes, and drug overdoses.
Proprietary name
Brand or trade name of a drug that is the patented property of the drug manufacturer; drugs of identical composition may have many different proprietary names
Pharmacologic antagonist
A drug that binds to its receptor without activating it
Physiologic antagonist
A drug that binds to a different receptor causing an effect that counteracts the effects of another agonist
Chemical antagonist
A drug that binds another drug and prevents the bound drug’s pharmacologic effect
Irreversible antagonist
A pharmacologic antagonist that cannot be overcome by
increasing the concentration of another agonist
Competitive antagonist
A pharmacologic antagonist that can be overcome by increasing the concentration of another agonist
Agonist
a drug that activates its receptor upon binding
Effector
component of the biologic system that accomplishes the biologic effect after being activated by the receptor; often a channel or enzyme.
Partial agonist
a drug that binds to its receptor but produces a smaller effect at full dosage than a full agonist
Quantal dose response curve
a graph of the fraction of its population that shows a specified response to increasing doses of a drug
Potency
the dose or concentration required to bring about 50% of the drug's maximum effect
Spare receptors receptors that do not have to bind drug in order for the maximum effect to be produced
Efficacy
maximum effect a drug can bring out regardless of does
Inert binding site
component of the biologic system to which a drug binds without changing any function