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18 Cards in this Set

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Antibiotic of choice for intracellular infections - Chlamydia, Rickettsia, Mycoplasma pneumoniae
Doxycycline
Antibiotic that is toxic so its used only topically for acne treatment
Minocycline
MOA for tetracyclines
30S inhibitor
Bacteriostatic
Interferes with reading of tRNA anti codon
MOA of chloramphenicol
Binds to 50S and inhibits peptide bond formation
Tetracyclines remain drug of choice for rare infections - what are they
Chancroid (H.ducrei)
Tularemia
Black plague
Brucellosis
Cholera
DOXYCYCLINE is the drug of choice
Alternative drug for anthrax
Doxycycline
Doxycycline elimination
- Forms complexes with fecal matter
- Does not accumulate in people with renal failure
2 tetracyclines with extensive liver biotransformation
Doxycycline
Minocycline
Adverse reactions of tetracyclines
GI - most common (diarrhea)
- Life threatening staphylococcal enterocolitis (bloody diarrhea)
- CNS
- Allergy
- PHOTOTOXICITY
- HEPATOTOXICITY
In older people using tetracyclines can lead to _
Negative nitrogen balance
Ability of tetracyclines to binds Ca can lead to _
Deposition in teeth and bones
Demeclocycline can cause_
Nephrogenic diabetes insipidus
Which drugs should not be used together with tetracyclines
Antacids
Milk and dairy products
Anti cholesterol drugs
Oral contraceptives
Barbiturates
Clinical use of chloramphenicol
- Meningitis
- Bacteremia
- BRAIN ABSCESS
Brain abscess
Drug of choice -
2nd best -
1st - chloramphenicol
2nd - ceftriaxone
Main adverse reaction of chloramphenicol
Aplastic anemia - drug goes to bone marrow and produces more fat then blood cells
Grey baby syndrome
- caused by giving chloramphenicol to neonates
- Abdominal distention, emesis, cyanosis, respiratory difficulty, finally vasomotor collapse and death
Drug interactions of chloramphenicol
- Inhibits P450 enzymes
- Do not combine with alfentanil (narcotic), phenytoin (anti seizure), anti coagulants