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21 Cards in this Set
- Front
- Back
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tricyclic antidepressants are used to treat ________
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major depression
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How do tca's work?
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block uptake of norepinephrine and serotonin
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how long do TCAs take to begin working
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2-4 wks
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What effect do TCA's have
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elevate mood, increase interest in daily living, decrease insomnia
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What are some of the major SE's of TCAs
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sedating, hypotension, carditoxicity
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what are some of major TCAs
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amitriptyline (Elavil), clomipramine (Anafranil), desipramine (Norpramin), doxipin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl), protriptyline (Vivactil), trimipramine (Surmontil)
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TCA SE's
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sedation, drosiness, blurred vision, dry mouth, eyes, urinary retention, constipation, wt gain, dizziness, nervousness, nausea, anoriexia, sexual dysfunction, skin issues (rash, pruritus)
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How do SSRI's work?
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block reuptake of serotonin into CNS. DO NOT BLOCK UPTAKE OF DOPAMINE OR NOREPINEPHERINE
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primary use of SSRI's
other uses of SSRI |
major depression (primary)
anxiety, OCD, panic, phobia, PTSD, eating disorders, drug abuse, PMS |
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Names of SSRIs
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fluoxetine (Prozac), fluvoxamine (Luvox)
sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro) |
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Many SSRIs have interaction with ________ that can lead to possible toxicity
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grapefruit juice
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SE Prozac
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dry mouth, blurred vision, insomnia, HA, nervousness, anorexia, nausea, diarrhea, suicidal ideation
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atypical antidepressants are used for ___________
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major depression, reactive depression, anxiety
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how do atypical antidepressants work
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they affect one or two of the three neurotransmitters serotonin, norepinephrine, and dopamine
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list atypical antidepressants
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amoxapine (Asendin)
bupropion (wellbutrin) maprotiline (Ludiomil) nefazodone (Serzone) trazodone (Desyrel) mirtazapine (Remeron) venlafaxine (Effexor) reboxetine (Vestra) |
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How do MAOIs work
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ezzyme monoamine oxidase inactivates norepinephrine, dopamine, epinepherine, serotonin. By inhibiting MO, levels of these neurotransmitters rise
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where are MAO-A and MAO-B found in the body
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liver and braion
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What does MAO-A inactivate
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dopamine
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what does MAO-B inactivate
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norepinephrine and serotonin
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what are the three MAOIs that are prescribed
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Tranylcypromine sulfate (Parnate), isocarboxazid (Marplan), and phenelzine sulfate (Nardil)
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what is the major risk of MAOIs?
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hypertensive crisis resulting from food and drug interactions
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