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16 Cards in this Set
- Front
- Back
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List the 4 G(+) antibiotics that don't have their own categories.
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Vancomycin
Quinupristin-Dalfopristin Linezolid Daptomycin |
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What is the MOA of Vancomycin?
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Inhibition of cell wall assembly, binding to D-Alanine. It is a time dependent bactreiocidal agent
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What is the MOR for Vancomycin?
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Mutation of D-Alanine to D-Lactate
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What bacteria does Vancomycin effect?
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G(+): MRSA, PRSP, MSSA,
G(-): NONE! Anerobes: C. Diff |
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What are the side effects of Vancomycin?
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Extreme erythema (lower drip rate)
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What is the MOA of Quinupristin-Dalfopristin?
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Binding to the 50S subunit, it is a time dependent bacteriostatic agent.
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What are the drug-drug interactions of Quinupristin-Dalfopristin?
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Statins (metabolized by CYP3A4)
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What are the bacteria effected by Quinupristin-Dalfopristin?
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Enterococci, used in VRE (E. Facieum, NOT Faecalis)
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What is the MOA of Linezolid?
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Binding to the 50S subunit. It is a time dependent bacteriostatic agent.
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What are three unique points to Linezolid?
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Oral Bioavailability
Crosses the BBB (think VRE meningitis) NOT contraindicated with statins |
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What bacteria are effected by Linezolid
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G(+): E. Faecalis and Faecium, MRSA, VRSA (reserved for complicated infections)
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What is the MOA of Daptomycin?
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Creates a hole in bacterial cell walls! It is a concentration dependent bacteriocidal agent.
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What are the bacteria effected by Daptomycin?
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VRE, used in PT's on SSRI's
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What are the side effects of Quinupresin-Dalfoprestin?
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Myalgia
Arthralgia Venous burning |
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What are the side effects of Linezolid?
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Serotonin syndrome (increased with SSRI's)
Thrombocytopenia/anemia |
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What are the side effects of Daptomycin?
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Myopathy
CPK elevations |
