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10 Cards in this Set
- Front
- Back
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Pharmacokinetics
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the study of drug movement through the body. The effect of the body on the drug.
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Absorption
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the movement of a drug from its administration site into the circulation
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Rate of Absorption
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how soon the effects of a drug will begin
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Amount of Absorption
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intensity of the drugs effects
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Factors affecting absorption
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rate of dissolution, surface area, blood flow, lipid solubility, pH partitioning,
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Rate of dissolution
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drugs in formulations that have rapid dissolution have a faster onset than drugs with slower rate of dissolution
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Surface Area
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the larger the surface area the faster the absorption. Small intestine has fastest absorption of oral administered drugs
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Blood Flow
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the more vascular a site the quicker the absorption. Works on concentration gradient, blood containing newly absorbed drug will be replaced rapidly by drug free blood.
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Lipid Solubility
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Highly lipid soluble drugs absorb more rapidly.
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pH partitioning
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drug absorption and elimination ca be affected by acid/base concepts. Also works on concentration gradient. Acid drugs are drawn toward alkaline and vice versa. Important in treatment of overdoses.
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