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12 Cards in this Set
- Front
- Back
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Pharmacology
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study of interaction of chemical substances with living systems
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Drug
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Any substance that brings change in biologic function through chemical action
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Receptor
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Specific regulatory molecule in biologic system where drug interacts - activates or inhibits normal body processes
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Agonist
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Drug that binds to receptor and stimulates cellular activity
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Antagonist
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Drug that binds to receptor and inhibits action of agonist - can be drug or endogenous agent
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Importance of drug size
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Lower limit allows specificity of drug action.
Upper limit determines extent of movement within body |
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Protein targets for drug binding
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1. Receptors
2. Enzymes 3. Carrier molecules 4.Ion channels 5. Structural proteins 6. Plasma proteins |
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Drugs that are not acting through receptors
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Chemical antagonists - binding stoichiometrically
Physiologic antagonists - adrenergic beta blockers Osmotic agents - mannitol for subarachnoid hemorrhage DNA - chemo drugs for cancer |
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Pharmacotherapeutic
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Refers to clinical condition for which drug is used
Imprecise - antibacterial, antviral Precise - antitubercular |
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Pharmacologic
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based on mechanism of the action of the drug including action of drug on system
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Pharmacodynamic
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Action of drug on body
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Pharmacokinetic
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Action of body on drug
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