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13 Cards in this Set

  • Front
  • Back
Significance of osteoporosis
- Loss of bone density
- Most common form of bone disease
- May be caused by genetics, nutrition, or other lifestyle issues
Osteoporosis
1- Primary: senile and postmenopausal
2- Secondary: anything that causes a Ca2+ deficiency (renal disease, dec Ca2+ in diet, vit. D deficiency, drugs-glucocorticoids & heparin)
Paget's Disease
Uncontrolled osteoclast activity
Bisphosphonates (7)
" the Dronates"
1- Alendronate*
2- Risedronate*
3- Tiludronate^
4- Ibandronate*
5- Etidronate^
6- Pamidronate*
7- Zoledronate*
* Aminobisphosphonate
^ Bisphosphonate
Bisphosphonate MoA and SE
- High affinity for Ca2+ so they incorporate into bone
- Directly inhibit osteoclast activity
- Bis. dec ATP production in osteoclasts
- Aminobis. inhibit an enzyme in a pathway to cholesterol synthesis (farnesyl pyrophosphate synthetase)

SE: GI upset, joint and muscle pain, eye inflammation, IV infusions (first dose effect), osteonecrosis of the jaw (BRONJ)
Teriparitide
- PTH analog; stimulates bone growth
- Inc osteoblast activity => long term is an inc in osteoclast
- Give in short Tx periods => Ca2+ deposition
Cinecalcet
- Ca2+ mimetic, sensitizes PTH Ca2+ receptors => dec PTH secretion
Raloxifene
- Estrogen analog; receptor modulator
- Inhibits osteoclast activity
- SE: pulmonary emboli, category X
Ergocalcitrol
Vitamin D analog
Fluoride
- Stimulates osteoblasts
Calcitonin
- Opposite effects of PTH
- Tx for Paget's disease- inhibits osteoclasts
- SE: nausea, metallic taste
Glucocorticoids (osteoporosis)
- Inhibit osteoblasts
- Heparin activates osteoclasts
Denosumab
- Blocks a receptor of NFkB (required for osteoclast activity)