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94 Cards in this Set
- Front
- Back
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Cephalosporins: 4 generations?
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1. more G +, hardly G -
2. less G+ more G - 3. hardly G+ mostly G -, CSF 4. Broad spectrum, resistance to beta lactimases, CSF |
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Cephalosporins: main adverse effect?
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c. diff
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Cephalosporins: allergic rxn
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1% cross allergy with pen's
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Cephalosporins: toxicity
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neuro in high doses
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Macrolides: Mech of act?
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50S- reversable
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Macrolides: metabolized by?
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liver
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Macrolides: serious side effects?
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Long QT
CYP enzyme inhibitor=increases other drugs |
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Macrolides: toxicity
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oto
hepatic |
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Tetracyclines: mech of act
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30s ribosomes-reversable
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Tetracyclines: don't take with?
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Ca++
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Tetracyclines: risks in preg?
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baby=brown teeth
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Tetracyclines: side effects
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heartburn
photo-sensitivity |
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Clindomycin: derived from?
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lincomycin
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Clindomycin: mech of act
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50s ribosome- irreversible
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Clindomycin: metabolized?
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liver
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Clindomycin: main cause of___
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c. diff
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Clindomycin: toxicity
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hepato
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Linezolid: mech of act?
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inhibit protein synthesis
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Linezolid: approved for only____
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MRSA, VRE
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Linezolid: don't use for people with
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PKU
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Linezolid: interacts with what meds?
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MAOI, SSRI
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Linezolid: can cause _____ suppression
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myelosuppression
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Fluoroquinolones: mech of act.
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disrupt DNA synthesis
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Fluoroquinolones: static or cidal?
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BACTERIOCIDAL
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Fluoroquinolones: excretion
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renal + hepatic
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Fluoroquinolones: new black box?
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achilles tendon rupture
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Fluoroquinolones: main CNS warning?
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can cause neurotoxicity in elderly
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Sulfonamides: excretion?
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renal
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Sulfonamides: can cause what syndrome?
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Steven Johnson
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Aminoglycosides: mech of action
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30s ribosome, irreversible
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Aminoglycosides: excretion
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renal
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Aminoglycosides: toxicity
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oto, renal
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Aminoglycosides: risks for increased toxicity
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prolonged therapy
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vanco: toxicity
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oto kidney
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vanco: static or cidal?
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cidal
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aminogly: cidal or static
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cidal
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vanco: excretion
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kidney
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vanco: G__ only
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+
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vanco: mech of act. close to?
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penicillins
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vanco: can cause _____ syndrome
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red man
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Rifampin: used primarily for
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TB, leprosy, MRSA
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Rifampin: can cause
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orange tears, pee
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Metronazole: main tx for___
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c. diff
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Daptomycin: mech of act
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injury to cell membrane
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Daptomycin kills almost all G ___
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+
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Azoles: take with
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cola
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Azoles to tx___
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athletes foot
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Amphotericin B: will almost always cause?
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renal injury, bone marrow suppression
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Amphotericin B: primarily used in patients with?
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immune-compromised
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Amphotericin B: stays in the body?
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1 yr +
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Azole: can increase___
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amt of other drugs in the body
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2006 consumer protection act?
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regulates serious adverse effects and reporting
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2007 good mfg processes
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labeled a supplement
no adulterants all ingredients listed |
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Whats not regulated in supplements
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adverse effects
dosage safety |
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Aloe uses?
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constipation
skin problems |
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aloe drug interactions?
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latex
don't take with diuretics |
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black cohosh taken for?
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menopause
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don't take black cohosh if you have?
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cancer or are on antiestrogens
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Co Q10: taken for
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myopathy from statins
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Co Q10 is similar to vit__
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K
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Co Q 10 and warfarin?
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co Q10 antagonizes warfarin
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Cranberry may increase?
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INR
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echinacea: allergy?
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don't take if allergic to daisy
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feverfew taken for?
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migrane prevention
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feverfew adverse rxn?
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post feverfew syndrome
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flaxseed may decrease
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LDL
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flax seed should not be taken____
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1 hr a meds
2 hr p meds |
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Garlic and platelets?
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anti-platelets
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Ginger and platelets?
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suppress platelet aggregation
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Ginko used for?
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memory & DAT & ED
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Ginko action
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vasodilation
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Ginko and coagulation?
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supression coagulation
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Ginko can decrease effects of?
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seizure meds
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Ginko can lower ___ threshold for some meds
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seizure
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St. JOhns wort used for?
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depression
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St Johns Wort interactions?
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interacts with MANY drugs
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Valerian root used for?
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insomnia
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Don't take glucosamine if you have a ____
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shell fish allergy
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Goldenseal interacts with?
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anticoagulants
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Saw Palmetto?
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tx of BPH
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saw palmetto and platelets
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anti-platelet effects
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3 main harmful supp?
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comfrey
kava Ma huang |
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The highest daily intake that can be consumed by nearly everyone without a sig. risk of adverse effects?
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Tolerable Upper Intake Limit (UL)
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Vit a deficiency causes?
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night blindness (rare)
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Vit A is highly____
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teratogenic
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vit E has __properties
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antioxidant
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vit E supp recommended for people who can not____
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absorb fat
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excess vit E can cause?
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bleeding
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Vit K is produced by?
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normal gut flora
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Vit K theraputic use?
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warfarin OD
in neonate to prevent bleeding |
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B3 deficiency?
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pallegra
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B1 deficiency?
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beriberi
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B12/b9 plays a role in?
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DNA synthesis
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b12/b9 deficiency can cause?
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anemia
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