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15 Cards in this Set
- Front
- Back
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NSAIDs
reduce pain and inflammation antipyretic and anti-inflammatory + analgesic |
inhibit pain mediators at the nociceptor level (short lived pain)
inhibit cyclooxygenase = enzyme that forms prostaglandin (PG produce pain through formation of free radicals) |
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Aspirin & Ibuprofen
what do they inhibit? |
inhibit cox 1 & cox 2
therefore they are nonselective |
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Celecoxib (celebrex) for...
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cox 2 inhibitor (make PG that are responsible for pain& inflammation)
selective long term chronic |
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remember about Aspirin (Cox 1 drug)
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it's a blood thinner
will have greater effect on blood coag greater risk for GI bleed |
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acetaminophen (tylenol) is NOT NSAID
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prototype for antipyretic
primary alternative to NSAID when pt can't take aspirin/ibuprofen |
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Aspirin (ASA) = Salicylate
mech of action |
as anticoagulant, antipyretic, anti-inflammatory, and analgesic
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Aspirin
Adverse effects |
with high doses may cause GI distress and bleeding
Adverse effects Irritates digestive system May cause bleeding Salicylism may occur: Tinnitus, dizziness, headache, excessive perspiration |
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NSAID adverse effect over long period of time
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platelet aggregation and GI upset
higher risk for gastric ulcerations |
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the only cox 2 inhibitor
because more harmful than good |
celebrex
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cox-1
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promotes renal blood flow
promotes platelet aggregation reduce gastric acid secretion |
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If a patient is on a coagulation drug be careful with giving them….
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aspiring because it's a cox-1 drug
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three most common NSAID
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aspirin
ibuprofen - prototype naproxin (naprosin) |
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Which is better? 325 mg or 81 mg of aspirin?
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They're are equally preventative
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acetaminophen/Tylenol does not effect
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pain/inflammation
it is an antipyretic |
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acetaminophen/tylenol maximum per day
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3 g/day
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