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DRUGS FOR SENSORY ORGANS

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What is glaucoma?

Leading cause of blindess where visual field loss is secondary to optic nerve damage

What is primary open angle glaucoma?

Most common, asymptomatic, progressive optic nerve damage with eventual impairment of vision. Aqueous fluid does not drain well out of the eye. (sink is clogged)

Risk factors for primary open-angle glaucoma

Elevation of intraocular pressure


African american


Family history


old age

what is it Angle closure glaucoma?

Acute onset, irreversible, preciptation by displacement of iris that prevents the exit of aqueous humor (Sink has bobble)

Corrective surgery for angle-closure glaucoma*******

Laser iridotomy


Iridectomy



Drug therapy for angle closure glaucoma*****

Doesnt do much, corrective surgery is the only solution

************Preferred route for glaucoma drug therapy******

Topical combined therapy

Surgical intervention to promote outflow of aqueous humor

Laser trabeculoplasty


Trabeculectomy

Example of a beta-adrenergic blocking agent for glaucoma********

Betaxolol,


levobetaxolol,


carteolol,


levobunolol,


metipranolol


timolol @


(usually end in -ol)

How do beta-adrenergic blocking agents work?******

Topicalbeta-blockers reduce the intraocularpressure (IOP) by blockade of sympathetic nerve endings in the ciliary epitheliumcausing a fall in aqueous humour production. used primarily for open-angle glaucoma

Beta-Adrenergic blocking agent patient education**********

Not optional drugs because they'll go blind if they dont use it. Stress importance of same time, same dose, every single day

Beta-Adrenergic blocking agent usual administration********

1-2 drops twice daily in conjuction with topical miotic which constricts the pupil

Adverse affects of beta-adrenergic blocking agents******

Local - Itching and burning (cotton in eye)


Systemic - Bradycardia, bronchospasm

Example of ▫Alpha2-adrenergicagonists and which is short term, long term*******

Brimonidine (Alphagan, long term), Apraclonidine (short term)

Adverse effects of alpha2-Adrenergic agonists********

Dry mouth, local burning and stinging, headache, blurred vision, foreign body sensation, itching

Example of ▫Prostaglandinanalogs *******

Latanoprost (Xalatan), lumigan, travatan Z

Prostaglandin analog adverse effects*********

permanent harmless brown pigmentation of the iris in ppl w/ hazel, blue, or light colored eyes

What are second line glaucoma drugs?

▫Cholinergic agonists▫Carbonic anhydraseinhibitors▫Nonselective adrenergicagonists

Glaucoma patient with asthma, which medication to give them?**********

Betaxolol or levobetaxolol instead of timolol b/c its beta-1 selective

What is pilocarpine?*************************************

It is a direct-acting cholinergic agonist that causes contraction of ciliary muscle and constriction of pupil to less than 2mm

Why is pilocarpine considered a 2nd line drug?********************

Side effects of itching and redness, DONT USE ANYMORE

How does pilocarpine work?*****************

Contraction of muscarinic receptor and ciliary muscle which constricts the pupil. This increased tension opens the trabecular meshwork through tension on scleral spur, increasing IOP outflow

How does echothiophate work?*********

It is a long duration cholinersterase inhibitor that inhibits breakdown of acetylcholine by promoting accumulation at muscarinic receptors

Echothiophate adverse effects and nursing considerations*********

No longer a first line drug. Causes myopia (near sightedness) and parasympathomimetric responses

Examples of carbonic anhydrase inhibitors and what they do*******

Dorzolamide, acetazolamide, methazolamide, that decreases production of aqueous humor that is generally well tolerated

Dorzolamide specific adverse effects*****

Ocular stinging, bitter taste, allergic reaction in 10-15%

General carbonic anhydrase inhibitor adverse effects********

Nervous system, teratogenic, acid-base disturbance, electrolyte imbalance

What do cycloplegics do?

Paralyze ciliary muscles resulting in loss of accommodation (unable to focus)

What do mydriatics do and example?***********

dilatethe pupil,usually due to topical application of muscarinic antagonists such as atropine, cyclopentolate, homatropine, scopolamine and tropicamide, phenylephrine

Purpose of cycloplegics and mydriatics

Intraocular exam and surgery, treatment of anterior uveitis

Averse effects of cycloplegics and mydriatics**********

Blurred vision and photophobia


Precipitation of angle closure glaucoma


Anticholinergic effects

What is allergic conjunctivitis

Itching, burning, watery discharge of conjunctiva as a result of biphasic immune response

What is the timeline of allergic conjunctivitis disease process?***********

Symptoms peak 20 minutes from exposure, lasts 20 minutes, then reappears 6 hours later

Treatment for allergic conjunctivitis

Mast cell stabalizer


H1 receptor antagonist


NSAIDs


Gluococoricoids


Advil

What is age-related macular degeneration?*******

Painless disease that blurs central vision and skews fine detail, leading cause of blindess believed to be from screens

Treatment for dry age-related macular degeneration

Antioxidants and zinc, vitamins, lutein

Treatment for wet age -related macular degeneration

Laser therapy


Photodynamic therapy


Angiogenesis inhibitors

THE SKIN

Adverse effects of topical glucocorticoids*********

Stretch marks, purpura, telangiectasia (spider web), hypertrichosis (excess hair), systemic toxicity (growth retardation, adrenal suppression)

What do topical glucocorticoids do?

Reduce inflammation and itching, drying agent

How to apply topical glucocorticoids*************

Thin film gently rubbed into skin. No occlusive bandages or clothes

What do keratolytic agents do?

Promote shedding of horny layer of skin

What does salicyclic acid treat?

Warts, corn

What does sulfur treat?

Acne, dandruff, psoriasis, seborrheic dermatitis

Drugs used to treat acne*********

Benzoyl peroxide


Clindamycin (Topical)


Tetracycline, isotretinoin (oral)


Retinoids such as tretinoin and adapalene and tazarotene

Oral antibiotics for acne*****

1st line - doxycycline, minocycline


2nd line - tetracycline, erythromycin

Nursing considerations for isotretinioin (accutane)*******

Teratogenic, triglycerides must be monitored

Difference between organic and inorganic sunscreen

Organic dissipates uv light and are chemical


Inorganic are physical and scatter uv light

Side effects of sunscreen

Acneburning, itching, or stinging of the skin


early appearance of redness or swelling of the skin


late appearance of rash with or without weeping blisters that become crusted, especially in sun-exposed areas, and may extend to unexposed areas of the skin


pain in hairy areas


pus in the hair follicles

What is psoriasis?***********

Erratic, chronic skin of Red patches with silver scales caused by accelerated maturation of epidermal cells and inflammation

********What is someone taking alefacept prone for?

Infection

*******Drugs for Psoriasis

Methotrexate - decreases skin cell production and supress inflammation


Acitretin


Corticosteroids


Cyclosporine - supresses immune system


Immunomodulator drugs

*****Nursing considerations for methotrexate and cyclosporin

Methotraxate can cause liver damage and decreased Whole blood


Cyclosporine increases risk of infection and cancer

What is actinic keratoses?***********

Rough scaly red or brown papules caused by chronic exposure to sunlight (half of skin cancers)

Drugs for actinic keratoses

Fluorouracil


Diclofenac sodium


Imiquimod


Aminolevulinic acid

Difference between psoriasis and eczema********

Psoriasis - white patch or red scaly, most commonly on knees and elbows, genetic, adults




Eczema - Self limiting and local, kids, raw and red, allergy, better to have

Topical immunosuppressants for eczema

Tacrolimus


Pimecrolimus

Drug used to remove venereal warts********

Podophyllin

Podophyllin consideration******

Must be applied by prescribing healthcare provider

Drugs for hairloss and mechanism of action

Topical minoxidil - takes up to 12 weeks to work




Finasteride - prevents testosterone conversion

Drugs for impetigo

Mupirocin


Retapamulin


Cephalexin


Dicloxacillin


Clindamycin


Amoxicillin

THE EARS

What is otitis media?

Inflammation of and fluid in the middle ear characterized by ear pain

How is otitis media diagnosed?

Acute onset of s/s


Middle ear effusion


middle ear inflammation


MUST HAVE ALL 3

Treatment for otitis media*******

80% of cases resolve by themselves but acetaminophen (best), ibuprofen, codeine can be given

What drug is used for antibiotic-resistant otitis media********

High dose amoxicillin-clavulanate

Prevention of otitis media

6 months breast feeding


Avoid child care centers if child has respiratory infections


Treat influenza


*******Vaccinate against streptococcus pneumoniae

Best way to prevent and treat recurrent otitis media*********

Treating influenza

Treatment for otitis externa

2% solution of acetic acid and alcohol as ear drops. Ciprofloxacin for adults and cephalexin for children

Necrotizing otitis externa

Rare, in high risk groups, where bacteria in EAC invade mastoid or temporal bone, causing meningitis and lateral sinus thrombosis

How to treat necrotizing otitis externa

Ear drops and IV


Oral ciproflaxacin

Fungal otitis externa

80-90% caused by aspergillus


Intense pruritus and erythema with or without pain or hearing loss. Treated with acidifying drops

CARDIAC DRUGS (RAAS)

How is the Renin- angiotensin - aldosterone stystem activated?**********************************************************************

Fall in blood pressure and imabalance of salt/water, decreased blood volume, and stimulation of kidney by sympathetic nervous system

How does the RAAS regulate blood pressure?

Constricts blood vessels and acts on kidney to promote retention of sodium and water and extretion of potassium

How does RAAS work?

Kidneys release renin which cuts off all but the first 10 amino acids called angiotensin 1. ACE then removes 2 of those amino acids, converting it to angiotensin 2, which signals adrenal gland to produce aldosterone that leads to increased salt and water retention (high blood pressure).

Indications for ACE inhibitors

Hypertension


HF


MI


Diabetic and nondiabetic nephropathy


Prevention of MI, stroke, and death

Drugs for hypertension is always included with a diuretic bradykinin to help lower blood pressure**********

Main adverse effects of ACE inhibitors***********

First dose hypotension


Teratogenic effects

ALL ACE INHIBITORS END IN -IL**********

Adverse effects of angiotensin II receptor blockers**********

Angioedema



Indicators for angiotensin II receptor blockers**********

Diabetic nephropathy*****


Heart failure


hypertension


MI, stroke

Eplerenone use

Hypertension, heart failure



Spironolactone use

Hypertension and heart failure

Spironolactone and Eplerenone Adverse effects***********

HYPERKALEMIA - first sign palpitations


Gynecomastia


Menstrual irregularities


Impotence


Hirsutism

CALCIUM CHANNEL BLOCKERS

How do calcium channel blockers work?

Prevent calcium from entering cells to regulate contractions and slow action potential of SA & AV node

Nifedipine & amilodipine use

Vasodilation by blocking calcium channels to lower BP, increase HR, and increase contractile force




Angina pectoris


HTX


Migraine/preterm labor

Adverse effects of Nifedipine & amilodipine

Flushing


Dizziness


Headache


peripheral edema


Gingival hyperplasia


Reflex tachycardia

Drug interaction with nifedipine & amilodipine**********

Beta-Adrenergic blockers

Verapamil use

Reduces myocardial oxygen demand and reverses coronary vasospasm to treat


angina pectoris


hypertension


cardiac dysrhythmias

Diltiazem use

Angina pectoris


Essential hypertension


Cardiac arrhythmias


Migraine

Diltiazem adverse effects

Constipation


Dizziness


Facial Flushing


headache


Edema of ankles and feet


Gingival hyperplasia

VASODILATORS

Adverse effects related to vasodilation**********

Postural hypotension


Reflex tachycardia


Expansion of blood volume

Hydralazine & minoxadil use

Hypertensive crisis


Heart failure

Hydralazine & minoxadil adverse effects

Reflex tachycardia


Increased blood volume


Systemic lupus erythematosus

Sodium Nitroprusside

Fastest antihypertensive agent with adverse effects of excessive hypotension, cyanide poisoning, thiocyanate toxicity

ANTIHYPERTENSIVES

Difference between primary and secondary hypertension

Primary- Idiopathic, treated but not cured




Secondary- primary cause, possible to treat, cure

****ALL ANTIHYPERTENSIVE THERAPIES START WITH DIURETICS******

Medication consideration for someone with both hypertension and asthma********

Cardiac specific beta blocker

Examples of diuretics used with hypertensive drugs

HCTZ


Lasix, Bumex


Aldactone

Examples of sympatholytics

Toprol


Alpha 1 blockers


Carvedilol and labetalol


Alpha 2 agonists


Adrenergic neuron blockers

Sodium nitroprusside Considerations******

Lowers blood pressure really really quickly

Fenoldopam considerations******

Causes arterial vasodilation leading to a decrease in blood pressure. Promotes sodium excretion. very short acting

Labetalol considerations********

IV push, very rapid drop in BP

Diazoxide consideration****

Potent potassium channel activator causing relaxation of smooth muscles

HEART FAILURE DRUG THERAPY

4 major goals of heart failure treatment*********************

–Reliefof pulmonary and peripheral congestive symptoms


–Improvefunctional capacity and quality of life


–Slowcardiac remodeling and progression of LV dysfunction


–Prolonglife

Vicious cycle of congestive heart failure**********

Cardiac dilation --> Activates sympathetic nervous system --> activates RAAS --> Increase in blood and water

Diagnosis for heart failure*********

Ejection fraction below 55%, stroke volume is amount being pushed out of the heart

Adverse effects of ACE inhibitors

Hypotension


Hyperkalemia


Intractable cough


Angioedema

Beta blocker action

Protects from excessive sympathetic stimulation and dysrhythmias

Beta blocker adverse effects******

FATIGUE LIKE YOUVE NEVER FELT BEFORE




Fluid retention


hypotension


bradycardia

Digoxin and cardiac glycosides*******

Increases strength of muscular contraction, increases myocardial contractile force without increasing energy expenditure,


alters electrical activity of the heart by slowing depolarization of pacemaker cells in av node

Normal BNP level*******

Less than 200

Beta Blocker is 1st line while Digoxin is 2nd line*******

Digoxin adverse effect********

Causes severe dysrhythmias




Anorexia, nausea, vomiting, fatigue

Hemodynamic effects of digoxin******

Decreased renin and sympathetic tone


Increased urine and sensitivity of baroreceptors

Patient teaching for digoxin******

Check pulses

Examples of sympathomimetics

Dopamine


Dobutamine

Examples of phosphodiesterase inhibitors

Inamrinone


Milrinone

Considerations and adverse effects for nitroglycerin****************

Causes coronary dilation, give sublingual




Hypotension


Resultant reflex tachycardia

Adverse effect of sodium nitroprusside********

Pass out from vasodilation and profound hypotension

Adverse effect of nesiritide*******

Symptomatic hypotension

ANTIARRHYTHMIC DRUGS

Where do fast potentials occur and what are the phases?

Fibers of his-purkinje system and atrial ventricular muscle




Depolarization


Repolarization


Plateua


Repolarization


Stable potential

Where do slow potentials occur and what are phases?

Cells of SA node and AV node




Slow depolarization


Absent


Depolarization

Quinidin effects on heart*******

DELAYS REPOLARIZATION




Blocks sodium channels


Slows impulse conduction


Blocks vagal input

Effects of quinidine on ECG*********

Prolongs the QT interval and ventricular polarization

Adverse effects of quinidine******

Cinchonism (can happen after 1 dose)




Diarrhea


Cardiotoxicity


Arterial embolism


Alpha adrenergic blockade

Lidocaine effects on the heart

Blocks cardiac sodium channels to slow conduction.


Reduces automaticity in ventricles and his-purkinje system


Accelerates repolarization

Adverse effects of lidocaine

CNS


Drowsiness


Confusion


Paresthesias

Flecainide and propafenone use & considerations

Blocks cardiac sodium channels and delays ventricular repolarization




However, exacerbates and creates dysrhythmias

Propanolol effects on heart and ECG

Decreased automaticity of SA node, velocity of conduction through AV node, and myocardial contractility

Propanolol use and adverse effect*******

Used for dysrhythmias caused by excessive sympathetic stimulation




Supreventricular tachydysrhythmias


BRONCHOSPASM


WORSENS ASTHMA AND COPD

Bretylium use and adverse effect

Ventricular fibrillation and tachycardia




Profound persistent hypertension and severe emesis

Amiodarone use and effect on ECG**********

For life threatening ventricular dysrhythmias




QRS widening and prolong of PR and QT intervals

Amiodarone adverse effects*******

Thyroiditis


Cardio and pulmonary toxicity

Varapamil and diltiazem use*******

Slow ventricular rate and terminates SVT caused by av nodeal reentrant circuit

Varapamil and diltiazem adverse effects

AV block


Heart failure


edema

Adenosine use****************************************************************

Termination of paroxysmal SVT

Adenosine medication administration**********

Very short half life, given IV push 6,6,12mg

Adverse effects of adenosine******

Sinus bradycardia


Dypsnea

AGENTS FOR CHOLESTEROL AND ELEVATED LIPIDS

Ideal cholesterol levels

LDL under 100


HDL above 40

Atorvastatin, simvastatin, crestor uses

Hypercholesterolemia


Primary and secondary prevention of CV events


Diabetes

Atorvastatin, simvastatin, crestor adverse effect*********

headache


myopathy/rhabdomyolysis


muscle fatigue

Nicotinic acid Adverse effects********

Skin flushing/itching


hepatotoxicity

Cholestyramine & Colestipol adverse effects

Constipation


Decreased uptake of fat soluble vitamins

Gemfibrozil adverse effects

Hepatotoxic


Rashes


Gallstones


myopathy

Ezetimibe adverse effects

Rhabdomyolysis


hepatitis


Pancreatitis


Thrombocytopenia

ANTI ANGINAL AGENTS

Chronic stable angina aggravating factors**********

Large meals


Cold exposure

Treatment focus for chronic stable angina********

Increase cardiac oxygen supply

What is variant angina?

Coronary artery spasm

What is unstable angina?

Angina at rest, new onset or intensification of existing angina

Adverse effects of nitroglycerin********

Headache


Orthostatic hypotension

Drug for percutaneous transluminal coronary angioplasty**********

integrillin and riopro

MANAGEMENT OF ST-ELEVATION MYOCARDIAL INFARCTION

What does tombstone t-wave show?

Death of cardiac muscle

What does MONA stand for in STEMI drugs?****************************

Morphine, oxygen, nitro, aspirine will decrease oxygen demand

DRUG THERAPY FOR THE DIGESTIVE TRACT

First pass effect

Liver removes big % of drug before reaching inferior vena cava. Dont give these drugs orally.

What is enterophepatic recirculation?

When drugs can recycled in the body because 95% of bile salts are reabsorbed back into the hepatic portal circulation

Two kinds of drugs that can lead to ulcers********

Corticosteroids and NSAIDS b/c they are prostaglandin antagonists

What is the purpose of somatostatin

Supresses gastrin, decreasing acid secretion

Duodenal ulcer pain************

Worse when stomach is empty, goes away with meals because the presence of food closes the pyloric sphincter and keeps acid in the stomach

Seriously ill or mechanically ventilated clients are treated prophylactically to prevent stress ulcers*******

Zolligner Ellison syndrome

Tumor secreting gastrin creastes over production of HCL, leading to ulcers

What does GERD do to the esophagus?***********

Injures esophageal tissue leading to barret's esophagus and possible cancer

DRUGS FOR PEPTIC ULCER DISEASE AND GERD

How do PPIs work?*********

Binds to hydrogen ions, inhibiting ATPase enzyme which stops stomach acid production

When to take PPI

20-30 min before first meal

PPIs end in -ZOLE********

Nursing concern for patient taking PPIs*********

If they have diarrhea, report it, do not treat

DO NOT TAKE PLAVIX WHEN TAKING PRILOSEC, REDUCES EFFECTIVENESS OF PLAVIX LEADING TO STROKE***********

What's so special about the PPI Aciphex?************

Only one reversible with shorter duration of action

Examples of PPI

Esomeprazole


Lansoprazole


Omeprazole


Pantoprazole


Rabeprazole

H2 RECEPTOR ANTAGONISTS

H2 RECEPTOR ANTAGONISTS END IN -DINE**********

Examples of H2 receptor antagonists

Cimetidine


Famotidine


Nixatidine


Ranitidine

Cimetidine administration*************

IV slow push over a minimum of 5 minutes

When and with what to take H2 Blockers with***************

With or right after meals, Antacids must be taken 2 hours before or after with full glass of water

H2 Blocker with dissolving tab for pediatric GERD**********

Ranitidine

Ranitidine adverse effects

Confusion, gynecomastia, impotence, loss of libido

Most potent H2 blocker

Famotidine

Which H2 blocker is not used for high incidence of adverse effects

Cimetidine

What is sucralfate?

Adheres to ulcer sites to repair them

How do bismuth compounds protect mucus?

Stimulates bicarb and prostaglandin so H.Pylori can't adhere to ulcerated tissue

Adverse effects of Misoprostol**************

Pregnancy category X


MUST NOT USE IN PREGNANCY


This is the abortion pill


Cytotec is combined with mifepristone to terminate pregnancies

PHARMACOTHERAPY OF BOWEL DISORDERS

LAXATIVES

Constipation is a medical emergency if........

Acute pain & abdominal distension

What are bulk-producing agents and administration of them**************

Gentlest of laxatives, causes stool be be bulky and retain water as well as emollient gel to help move along.


SHOULD BE TAKEN WITH PLENTY OF WATER

Surfactant laxatives

Lowers surface tension of water, well-received

Stimulant laxatives

Act on intestinal mucosa or nerve plexus to alter water and electrolyte secretion

Examples of osmotic laxatives***********

Saline Agents


Milk of magnesia


Magnesium citrate

What does lactulose do in the body?*******

Retains colon water, lowering pH and increasing colonic peristalsis. Reduces ammonia levels in liver disease. Also indicated for use in portal-systemic encephalopathy

When is whole bowel irrigation used? and what solutions?*************

Prepare bowel for surgery or colonoscopy




Sodium bicarb, sodium chloride, potassium choloride

DIARRHEA

When are antidiarrheals contraindicated in diarrhea?******** and why?

Diarrhea caused by poisoning, infection with toxin producing organisms, C.diff infection




Fatal toxic megacolon can result!

Loperamide nursing considerations**********

No narcotic effect, not controlled substance


Low doses OTC, high dose Rx


Tablet, capsule, liquid

Long term adverse effects of Oral corticosteroids***********

Infection, hyperglycemia

Azathioprine (Imuran) nursing consideration*********

Monitor CBC w/ differential b/c rare type of t-cell lymphoma has been reported

Action of Sulfasalazine**************

Inhibits mediators of inflammation in colon and reduces inflammation associated with ulcerative colitis

IRRITABLE BOWEL SYNDROME

Alosetron nursing consideration

Black box warning, no refills without follow up from provider

Dicyclomine adverse effect

Dry mouth, blurred vision, drowsiness, urinary hesitancy, tachycardia

Nursing consideration for lubiprostone***********

DO NOT GIVE TO CLIENTS WITH DIARRHEA OR GI OBSTRUCTION, PREGANANCY CATEGORY c

DRUGS FOR OBESITY

Sibutramine Adverse effects

Headache, constipation, insomnia

Orlistat adverse effects

GI effects


Reduced absorption of fat soluble vitamins

Phentermine adverse effects***********

Dry mouth


Tachycardia


Flushing


Insomnia


Dizziness


Tolerance

What is scopolamine and adverse effects?**********

Anticholingergic transdermal patch




Drowsiness and blurred vision

Phenothiazines adverse effect*********

Sedation and extrapyramidal symptoms

Prochoperazine contraindication*********

Black box warning, death in elderly with dementia


DO not use in comatose or CNS depression