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23 Cards in this Set

  • Front
  • Back
Orlistat
-Mechanism
Alters fat metabolism by inhibiting pancreatic lipase
Orlistat
-Clinical Use
Long-term obesity management
Orlistat
-Toxicity
Steatorrhea, GI Discomfort, reduced absorption of fat-solube vitamin, headache
Sibutramine
-Mechanism
Sympathomimetic serotonin and norepinephrine reuptake inhibitor
Sibutramine
-Clinical Use
Short-term and long-term obesity management
Sibutramine
-Toxicity
Hypertension and Tachycardia
Propylthiroauracil
-Mechanism
A. Inhibits organification and coupling of thyroid hormone synthesis. B. Decreases conversion of T4 to T3 (Methimazole only does A)
Propylthiorauracil
-Clinical use
Hyperthyroidism
Methimazole
-Toxicity
Same as Propylthiouracil
Skin rash, agranulocytosis, aplastic anemia
Somatostatin
-Clinical use
Acromegaly, carcinoid, gastrinoma, glucagonoma
Growth Hormone
-Clinical Use
Turner's syndrome and GH deficiency
Oxytocin
-Clinical Use
Stimulates labor, uterine contractions, milk let-down; controls uterine hemmorrhage
Desmopressin
-Clinical Use
Pituitary (central, not nephrogenic) DI (ADH)
Levothyroxine
-Mechanism
Thyroxine replacement
Also triiodothyronine
triiolodthyronine
-Clinical use
Hypothyroidism, myxedema
Same as Levothyroxine
Triiodothyronine
-Toxicity
Tachycardia, heat intolerance, tremors, Arrhythmias
Glucocorticoids (-thasone)
-Mechanism
Decreases the production of leukotrienes and prostaglandins by inhibiting phospholipase A2 and the expression of Cox-2
Hydrocortisone
-Clinical use
Glucocorticoid
Addison's disease, inflammation, immune suppression, asthma
Triamcinolone
-Toxicity
Iatrogenic cushing's syndrome-->Buffalo hump, moon facies, truncal obesity, muscle wasting, thin skin, easy bruisability, osteoporosis, adrenocortical atrophy, peptic ulcers, diabetes
Demeclocycline
-Mechanism
ADH antagonist (tetracycline family)
Demeclocycline
-Clinical use
Diabetes Insipidus, SIADH
Demeclocycline
-Toxicity
Photosensitivity, abnormalities of bone and teeth
Megestrone
-Clinical use
Used for weight gain (synthetic oral progrestin)