Pharmacology Drugs Test 2 Winter 2012

Front 1

Acetylcholine

Back 1

Cholinergic Agonist: N,M
does not cross the BBB
rapidly metabolized
nerve trans: PNS-pre/post
SNS: all pre(some post->sweat glands)
nicotinic and muscarinic receptors

Front 2

Muscarine

Back 2

Cholinergic Agonist: M
Alkaloid
sensitive to salivation & sweating
muscarine from mushrooms

Front 3

Nicotine

Back 3

Cholinergic Agonist: N
smoking
low dose: CNS stim, alertness, attention
high dose: toxicity, tremer, vomiting, hypertension

Front 4

Methacholline

Back 4

Cholinergic Agonist: M
Dx Asthma
use atropine to reverse effects

Front 5

Pilocarpine

Back 5

Cholinergic Agonist: M1, M3
Glaucoma, decreas IOP, increase salivation & sweating
Myosis

Front 6

Bethanechol

Back 6

Cholinergic Agonist: M
GI stim, decrease Urinary retention
does no cross BBB
resistant to AChE
muscarinic specific receptors
SE: increased sweating, cramps, diarrhea

Front 7

Carbachol

Back 7

Cholinergic Agonist: M, N
Glaucoma,used only in the eye
decrease IOP
pupil constriction
No BBB
resistant to AChE
nicotinic and muscarinic receptors

Front 8

Cevimeline
(Evoxac)

Back 8

Cholinergic Agonist: M3
increase salivation, dry eyes, SJOGRENS
SE: sweating

Front 9

Varenicline (chantix)

Back 9

Cholinergic Agonist:N
relieve nicotine craving/ smoking cessation
SE: N/V, constipation, dream patterns, behavioral changes

Front 10

Donepezil

Back 10

Cholinesterase Inhibitors:
Alzheimer's disease

Front 11

Physostigmine

Back 11

Cholinesterase Inhibitors
Glaucoma, decrease IOP
crosses BBB, 2-4 hours
treatment of atropine overdose
SE: brady, convulsions

Front 12

Neostigmine

Back 12

Cholinesterase Inhibitors
Tx: Myasthenia Gravis,
reverses NM blockade, increase bladder motility
no BBB, increase para effects
ONLY PNS effect 2-4 hrs

Front 13

Edrophonium

Back 13

Cholinesterase Inhibitors
Dx: Myasthenia Gravis, short acting
10 minutes, increase muscle strength, decreased muscle strength if too high of a dose

Front 14

Malathion

Back 14

Cholinesterase Inhibitors
organophosphate
pesticides, lipid soluble
reversed by Atropine and 2-PAM

Front 15

Pralidoxime (2-PAM)

Back 15

Cholinesterase Inhibitors
Reverse organic poisoning, reactivates AChE
atropine +2-PAM given to reduce O-PO4 poisoning, must be used before again occurs

Front 16

Atropine

Back 16

Cholinergic Antagonist:
decrease vagal tone, revese AV block or muscarinic-induced brady
OD: dry as a bone, blind as a bot, red as a beet
No BBB, BBB
Tx: chol inhib
counteract pesticide or nerve gas

Front 17

Ipratropium

Back 17

Cholinergic Antagonist:
COPD, acute asthma, broncodilator
SE: dry mouth, myadriasis & cyclopegia, decrease GI motility, urinary retention and tachy

Front 18

Scopalamine

Back 18

Cholinergic Antagonist:
motion sickness
same SE as atropine

Front 19

Tolterodine

Back 19

Cholinergic Antagonist: M3
Tx overactive bladder
same SE as atropine

Front 20

Epinephrine

Back 20

Adrenergic stimulants: a1, a2, b1, b2
Anaphylactic shock, cardiac arrest, complete heart block, emergent asthma, decrease diffusion of local anesthetic
SE: tremors, shaking, tachy, angina, increased BP

Front 21

Norepinephrine

Back 21

Adrenergic stimulants: a1,a2,b1
possibly for severe HTN
SE: severe vasoconstriction, increase BP

Front 22

Phenylephrine

Back 22

Adrenergic stimulants: a1, a2
nasal decongestant

Front 23

Dobutamine

Back 23

Adrenergic stimulants: b1
CO in cardiogenic shock, stress test

Front 24

terbutaline

Back 24

Adrenergic stimulants: b2
stop premature labor, FA bronchodilaltor

Front 25

Clonidine

Back 25

Adrenergic stimulants: a2
HTN, hot flashes, pre-anesthetic
SE: dry mouth, sedation, sex dys fxn

Front 26

Albuterol

Back 26

Adrenergic stimulants: b2
Asthma

Front 27

Isoproterenol

Back 27

Adrenergic stimulants: b1, b2
emergency Tx of: cardiac arrest
complete heart block, bronchospasm

Front 28

Cocaine

Back 28

Adrenergic stimulants: inhibition of reuptake of NE

Front 29

Amphetamine

Back 29

Adrenergic stimulants: Displaces NE, increase NE
abuse, ADHD

Front 30

Tyramine

Back 30

Adrenergic stimulants: displaces NE, increase NE, in foods, bad rxn with MAOI

Front 31

Labetolol

Back 31

Adrenergic blocking agents: a1, b1, b2
HTN emergencies

Front 32

Propranolol

Back 32

Adrenergic blocking agents: B
MI, HTN, migraine prophylaxis, angina, arrhythmias, hyperthroidism, stage fright, CHF
Never give asthmatics

Front 33

Yohimbine

Back 33

Adrenergic blocking agents: a1
natural viagra

Front 34

Doxazosin

Back 34

Adrenergic Blocking Agents: a1
HTN, BPH (BID)
SE: ED, postural HTN, syncope

Front 35

Tamsulosin

Back 35

Adrenergic Blocking Agents: a1-A
BPH, no change BP
SE: ED

Front 36

Carvedilol

Back 36

Adrenergic Blocking Agents:a&b
CHF, HTN, p MI

Front 37

Prazosin

Back 37

Adrenergic blocking agents: a1
HTN, BPH (BID at least)
SE: dizziness, decrease ejection

Front 38

Metoprolol

Back 38

Adrenergic blocking agents: b1
MI, HTN, migraine prophylaxis
never give asthmatics

Front 39

Phenoxybenzamine

Back 39

Adrenergic Blocking Agents: a
pheochromocytoma

Front 40

Phentolamine

Back 40

Adrenergic Blocking Agents: a
short-term tx of HTN crisis, decrease peripheral resistance
CI: ED drugs

Front 41

Succinylcholine

Back 41

N.M. Jxn and ganglion blocking agents: Depolarizing, IRREVERSIBLE; muscle relaxation/intubation, rapid metabolization
SE: increase K+-> cardiac problems, no antidote for OD

Front 42

d-tubocurarine

Back 42

N,M Jxn and ganglion blocking agents: NON-depol
Paralysis of skeletal muscle in surgey-slow excretion/long acting
SE: (histamine release) hypotension bronchspasm, no BBB, AChE inhib to reverse OD

Front 43

Timolol (Timoptic)

Back 43

Adrenergic receptor antagonist:
used in glaucoma, reduce IOP

Front 44

Miosis

Back 44

parasympathetic M1, M2

Front 45

Acommodation

Back 45

parasympathetic M3, M2

Front 46

Lacrimation

Back 46

parasympathetic M3, M2

Front 47

Mucus secretion

Back 47

parasympathetic M3, M2

Front 48

Salivation

Back 48

parasympathetic M3, M2

Front 49

Brochoconstriction

Back 49

parasympathetic M2=M3

Front 50

decreased Heart rate

Back 50

parasympathetic M2

Front 51

decreased atrioventricular conduction

Back 51

parasympathetic M2

Front 52

increase hydrochloric acid secretion

Back 52

parasympathetic M3, M2

Front 53

increased motility

Back 53

parasympathetic M3, M2

Front 54

micturition

Back 54

parasympathetic M3

Front 55

Erection

Back 55

parasympathetic M3

Front 56

Mydriasis

Back 56

Sympathetic a1

Front 57

Vasoconstriction

Back 57

Sympathetic a1

Front 58

Salivation

Back 58

Sympathetic a1

Front 59

Sweating

Back 59

Sympathetic M3, M2

Front 60

Brochodilation

Back 60

Sympathetic b2

Front 61

increased heart rate

Back 61

Sympathetic b1

Front 62

increased atrioventricular conduction

Back 62

Sympathetic b1

Front 63

increased contractility

Back 63

Sympathetic b1

Front 64

Glycogenolysis

Back 64

Sympathetic b2

Front 65

decreased motility

Back 65

Sympathetic a and b

Front 66

renin secretion

Back 66

Sympathetic b1

Front 67

urinary retention

Back 67

Sympathetic a1

Front 68

uterine relaxation

Back 68

Sympathetic b2

Front 69

ejaculation

Back 69

Sympathetic a1