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108 Cards in this Set
- Front
- Back
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NE
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alpha 1, beta 1
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Ep
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alpha 1
beta 1,2 |
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amphetamine
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alpha 1
beta 1 |
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ephedrine
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alpha 1
beta 1,2 |
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pseudophedrine
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alpha 1
beta 1,2 |
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alphamethyl dopa
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alpha 1
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clonidine
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alpha 1
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guanabenz
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alpha 1
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phenylephrine
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alpha 1
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methoxamine
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alpha 1
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metaraminol
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alpha 1
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isoproterenol
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beta 1,2
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dobutamine
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beta 1
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dopamine
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beta 1
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terbutaline
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beta 2
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metaproterenol
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beta 2
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albuterol
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beta 2
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ritodrine
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beta 2
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prazosin
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alpha 1 antagonist
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phentolamine
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alpha 1 antagonist
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phenoxybenzamine
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alpha 1,2 antagonist
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propranolol
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beta 1,2 antagonist
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pindolol
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beta 1,2 antagonist
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metoprolol
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beta 2 antagonist
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atenolol
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beta 2 antagoinst
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labetalol
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alpha 1
beta 1,2 antagonist |
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carvedilol
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alpha 1
beta 1,2 antagonist |
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timolol
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beta 1,2 antagonist
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metyrosine
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NE synthesis blocker
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reserpine
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NE depleter
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guanethidine
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NE depleter
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cocaine
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NE re-uptake blocker
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imipramine
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NE re-uptake blocker
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tranylcypromine
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MAO inhibitor
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phenelzine
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MAO inhibitor
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what area of the brain does NE work at?
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locus coeruleus
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what is NE metabolized to?
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Vanillylmandelic acid- VA
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tumor of the adrenal gland?
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pheochromocytoma
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contraindications with Ep?
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MAO inhibitors
halothane-sensitizes myocardium to catecholamines |
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main alpha 1 agonists?
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metaraminol
phenylephrine |
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what drug is used for a sustained rise in BP?
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metaraminol
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what drug is used to dilate the pupil but not affect accomodation, also used in glaucoma?
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phenylephrine
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what are the main alpha 2 agonists?
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alpha-methyldopa
clonidine guanabenz |
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what drug is used in hypertensive pregnant women to decrease BP?
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alpha-methyldopa
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main alpha 1,2 antagonists?
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phenoxybenzamine
phentolamine |
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main alpha 1 antagonists?
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prazosin
doxazosin terazosin tamsulosin |
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what drug is used in treatment of peripheral vascular disease?
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phenoxybenzamine
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what drug is used to diagnose pheochromocytoma?
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phentolamine
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beta 1 agonists?
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dopamine, dobutamine,
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mixed beta agonists?
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isoproterenol
ephedrine Ep |
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what drug is used to relieve dysmenorrhea?
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ephedrine
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what drug causes a fall in BP with a rise in HR and CO?
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isoproterenol
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which drug is used in shock to carefully increase sympathetic activity?
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dopamine
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which drug is used in heart failure to avoid hypertension?
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dobutamine
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what are the main beta 2 agonists?
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metaproterenol
turbutaline albuterol salmeterol ritodrine |
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what drug is used for management of premature labor?
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ritodrine
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what is the most selective beta 2 agonist?
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salmeterol
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main beta blockers?
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propranolol
pindolol timolol labetalol carvedilol |
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contraindications of propranolol?
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asthma, peripheral vascular disease and insulin dependent DM
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beta blocker with partial agonist activity and low rebound affect?
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pindolol
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drug used in prevention of reinfarction?
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timolol
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beta-blocker used in heart failure?
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carvedilol
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drug used in treating hypertension of pheochromocytoma and hypertensive crisis?
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labetalol
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main beta 1 blockers?
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metoprolol
atenolol acebutolol |
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drug used to treat hypertension in patients with asthma, insulin dependent DM and peripheral vascular disease?
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metoprolol
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contraindication of metoprolol?
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congestive heart failure
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drug used once a day for hypertension?
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atenolol
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sites of nicotinic receptors?
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NMJ
adrenal medulla sym. and para ganglion |
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main muscarinic agonists?
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bethanechol
carbachol methacholine muscarine pilocarpine |
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what drug is used to selectively contract the bladder and GI tract?
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bethanechol
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what drug is used to test for asthma and why?
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methacholine- hyperactivity of bronchioles
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what drug is used to treat glaucoma?
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pilocarpine- unblocks trabeculae
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what are the main muscarinic antagonists?
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atropine
scopolamine |
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anti-parkinsonism drugs?
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trihexyphenidyl HCL
Benztropine Mesylate |
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most important use of NMJ blockers?
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muscle relaxation during surgical anesthesia
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main anticholinesterases?
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neostigmine
pyridostigmine edrophonium |
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NMJ antagonists?
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curare
succinylcholine |
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what is the main nicotinic antagonist?
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mecamylamine
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what drug is used to treat atropine poisoning?
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physostigmine
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which drug blocks the activity of tyrosine hydroxylase and is used to control pheochromocytoma?
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alpha-methyltyrosine
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which drugs decrease sympathetic outflow by stimulating alpha two receptors at the vasomotor center?
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alpha methyldopa
clonidine guanabenz |
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what is administered with L dopa to decrease the sympathetic side effects by inhibiting AAAD?
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carbidopa
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which drugs are used to displace NE from stored pools?
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amphetamine
tyramine |
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which drug works gradually to decrease BP by blocking NE vesicular uptake and is contraindicated in depressed patients?
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reserpine
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which drug competes for NE storage sites and causes an initial rise in BP due to NE displacement?
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guanethidine
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which reuptake inhibitor works selectively for NE?
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desipramine
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which reuptake inhibitor works selectively for DA?
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buproprion
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which monoamine does amitriptyline work most for?
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5HT>NE
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which monoamine does nortriptyline work most for?
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NE>5HT
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what is the irreversible MAO inhibitor?
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phenelzine
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what is the reversible MAO inhibitor?
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tranylcypromine
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which drug works selectively to inhibit MAO B to battle Parkinson's?
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selegiline (deprenyl)
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characteristics of curare?
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poorly absorbed, no BBB
urinary excretion histamine release long acting |
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characteristics of pancuronium?
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5X potency of curare
urinary excretion little histamine release blocks M2- tachycardia |
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which NMJ blocker is spontaneously broken down in plasma, and whose breakdown product make cause seizures?
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atracurium
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which NMJ blocker is 10 more potent that curare, is metabolized by the liver and does not release histamine?
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vecuronium
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characteristics of mivacurium?
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short duration of action
cholinesterase metabolism like curare, but short action |
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which NMJ blocker has the most rapid onset, and is preferred anesthetic if succinylcholine is not desired?
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rocuronium
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characteristics of succinylcholine?
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rapid onset and short DOA
hydrolyzed by cholinesterase little histamine release K release- hyperkalemia hyperthermia- increase Ca release increase intraocular P |
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contraindication of succinylcholine?
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low cholinesterase levels- apnea
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what are the Na channel blocker toxins and where do they come from?
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tetrodotoxin- puffer fish
saxitoxin- dinoflagellates |
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which toxin causes Na influx with initial hypermovement and eventual paralysis?
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batrachotoxin
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characteristics of alpha bungarotoxin?
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curare analog
found in asian snake muscle weakness and paralysis |
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which toxin causes an ACh release blockade and what are the effects?
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botulinum toxin
absence of muscarinic action loss of tone, fatigue and paralysis respiratory arrest |
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which toxins cause an ACh flood with excess muscarinic action and skeletal muscle hyperactivity?
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latrotoxin- black widow
beta-bungarotoxin |
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which drug is an anticholinesterase with direct stimulating action on skeletal muscle use in myasthenia gravis?
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neostigmine
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effects of pentolinium?
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fall in BP
increase in HR reduced GI motility and tone |
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what drug causes an epi-reversal?
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phentolamine- alpha blocker
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