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7 Cards in this Set
- Front
- Back
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Define renal excretion.
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It is the major mechanism for elimination of water soluble (polar) compounds
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How does glomerular filtration follow first order kinetics?
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The amount of drug filtered per unit time is proportional to the concentration of free drug is plasma
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What is the fate of lipid soluble drugs?
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They are reabsorbed into plasma
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What is the fate of lipid insoluble drugs?
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They are excreted in urine
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Define renal clearance.
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It is the volume of plasma that is completely cleared of a substance by the kidney per unit time
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When does maximal renal clearance occur?
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It occurs when the drug is completely filtered and secreted and no reabsorption occurs
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If the drug is only filtered, what is the renal clearance equal to?
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125 ml/min, the GFR
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