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7 Cards in this Set

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Define renal excretion.
It is the major mechanism for elimination of water soluble (polar) compounds
How does glomerular filtration follow first order kinetics?
The amount of drug filtered per unit time is proportional to the concentration of free drug is plasma
What is the fate of lipid soluble drugs?
They are reabsorbed into plasma
What is the fate of lipid insoluble drugs?
They are excreted in urine
Define renal clearance.
It is the volume of plasma that is completely cleared of a substance by the kidney per unit time
When does maximal renal clearance occur?
It occurs when the drug is completely filtered and secreted and no reabsorption occurs
If the drug is only filtered, what is the renal clearance equal to?
125 ml/min, the GFR