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20 Cards in this Set
- Front
- Back
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What are the 3 factors that controls the penetration of drug into the cell via diffusion?
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Molecular size
Lipid solubility Degree of ionisation |
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hydrophilic polar drugs are often limited to...
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extracellular fluid
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hydrophobic nonpolar drugs interact with which type of receptor
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intracellular
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The brain only allows paracellular diffusion (True/false)
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False the brain has a tight junction and do not allow paracellular diffusion
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Drugs must be (lipohilic/lipophobic) and take the (transcellular/paracellular) route to diffuse quickly into the brain
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lipohilic
transcellular |
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What is the membrane protein that actively pump drugs out of the brain and back into the blood?
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P glycoprotein
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hydrophilic drugs must bind to ................... to be able to diffuse into the blood brain barrier
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carrier-mediated transport
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L-DOPA is an important drug for the treatment of what disease
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Parkinson's disease
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L-DOPA is transported into the brain by the __-system which transports large neutral amino acids into the CNS
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L-system
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Rapid penetration into the CNS is important for which type of drug?
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anti-convulasant
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The placenta can act as a metabolic barrier because it contains a variety of enzyme systems espically oxidases such as....
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cytochrome P450
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The Placenta also contains _______ which transports substrate molecules back into maternal blood
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P-glycoprotein
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The blood capillaries in the testis have _______ that acts as the blood testis barrier
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tight junction
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blood flow _______ is the rate limiting step in the distribution of lipid soluble drugs
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perfusion
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Thiopental induces _______ within 30-60 seconds of i.v. injection but its duration of action is only several minutes
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anaesthesia
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Thiopental accumulates and is redistributed to which type of organ?
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skeletal muscle and fat
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hydrophilic (polar) or large molecular weight tend to penetrate tissues that have a relatively ______ blood-tissue boundary
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porous
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Benzypenicillin exhibits ______________ distribution
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permeability-rate limited
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what is the term for when the cancentration of drug in the tissue is higher than the concentration of drug in the plasma?
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sequestration or accumulation
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Highly lipid soluble drugs readily dissolve and accumulate in...
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adipose (fat) tissue
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