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40 Cards in this Set

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What are the types and specific coticosteriods?
Glucocorticoids - cortisol
mineralcorticoids - aldosterone
androgens - testosterone, estradiol
What are the functions of glucocorticoids?
fat metabolism
CHO metabolism
Protein metabolism
anti-inflammatory
immunosuppressive
What is the function of mineralocorticiods?
maintain fluid and lyte balance
What is the function of androgens?
Sex characteristics
Corticosteriods are secreted from what part of the adrenal gland?
The cortex
What are the types and specific coticosteriods?
Glucocorticoids - cortisol
mineralcorticoids - aldosterone
androgens - testosterone, estradiol
What are the functions of glucocorticoids?
fat metabolism
CHO metabolism
Protein metabolism
anti-inflammatory
immunosuppressive
What is the function of mineralocorticiods?
maintain fluid and lyte balance
What is the function of androgens?
Sex characteristics
Corticosteriods are secreted from what part of the adrenal gland?
The cortex
What are the types and specific coticosteriods?
Glucocorticoids - cortisol
mineralcorticoids - aldosterone
androgens - testosterone, estradiol
What are the functions of glucocorticoids?
fat metabolism
CHO metabolism
Protein metabolism
anti-inflammatory
immunosuppressive
What is the function of mineralocorticiods?
maintain fluid and lyte balance
What is the function of androgens?
Sex characteristics
Corticosteriods are secreted from what part of the adrenal gland?
The cortex
What are the types and specific coticosteriods?
Glucocorticoids - cortisol
mineralcorticoids - aldosterone
androgens - testosterone, estradiol
What are the functions of glucocorticoids?
fat metabolism
CHO metabolism
Protein metabolism
anti-inflammatory
immunosuppressive
What is the function of mineralocorticiods?
maintain fluid and lyte balance
What is the function of androgens?
Sex characteristics
Corticosteriods are secreted from what part of the adrenal gland?
The cortex
Aldosterone tells the body to ___________ to fluids which (exacerbates/inhibits) further renin-angiotension release.
HOLD ON TO
inhibits
What are some of the therapeutic uses of corticosteriods?
Endocrine disorders, rheumatic disorders, dermatologic disorders, allergic conditions, opthalmic disorders, neoplastic diseases, GI diseases (crohns) rispiratory diseases, immunosuppression, unlabled uses
What are the implications behind the A/E of adrenal suppression?
Some pts may see a decreased secretion of endogenous corticosteriods after prolonged use of corticosteriods. This is dose dependent. Watch for s/s of adrenal insufficiency (nausea, fatigue, hypotension, hypoglycenia, myalgia, fever, dizziness.)
How would musculoskelegal A/E resulting from corticosteriods manifest?
Muscle wasting and weakness, osteoporosis, vertebral compression fractures.
Would you see an immune reponse resulting from corticosteriod use?
Yes, possible suppression of immune responses.
What endocrine-related a/e might you see in a pt on glucocorticoids?
cushings syndrome, growth suppression, amenorrhea, hyperglycemia, exacerbate diabetes mellitis
What are the fluid/lyte imbalance a/e to expect?
Na and H2O retention->edema, hypokalemia, alkalosis, hypertension, CHF
Hypocalcemia
Any ocular a/e?
increased ocular pressure-->cataracts, glaucoma, optic nerve damage, blindness
GI a/e?
Pancreatitis, ulcerative esophagitis, peptic ulcers
CNS a/e?
Mental disturbances, headache, vertigo, insomnia, seixures, increased ICP
Dermatologic a/e?
impaired wound healing, hirsutism, petechiae and ecchymoses
hypersensitivity a/e?
Allergic rxn, hives, itching burning
cardiovascular a/e?
hypokalemia -> arrhythmias
worsening htn
emboli
left ventricular free wall rupture after MI
What are precautions and contraindications for glucocorticoids?
pregnancy
lactation
children-->impaired growth
infections
postMI, infection, hypersensitivity, PUD
What are the short acting CS?
Cortisone
hydrocortisone
What are the intermediate acting CS?
Prednisone
Prednisoline
triamcinolone
methylprednisolone
When should GC be given?
Prior to 9am
Dosage depends upon:
diagnosis
severity of disease
patient response
Why would one suggest alternate day therapy with GCs?
For pts on long term therapy it may reduce side effects.
Use intermediate acting ones.
When d/cing Gcs, what should one do?
Gradually taper the dose.