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18 Cards in this Set
- Front
- Back
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What are unwanted drug effects often referred to?
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adverse drug reactions
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What type of curve shows the frequency of volunteers to increasing sensitivity to drug effect?
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Bell curve
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What does TD50 stand for?
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toxic effect in 50% of patient population
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What does the therapeutic index measure?
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Drug safety
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How is TI calculated?
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TD50/ED50
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The larger the value of TI the (greater/lower) the margin of safety
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greater
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What is the ideal TI
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TD1/ED99
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(Hypersusceptibility reactions/Collateral effects/side effects/Toxic effects) is unwanted effects occurring below normal dose range
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hypersusceptibility
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(Hypersusceptibility reactions/Collateral effects/side effects/Toxic effects) is unwanted effects occurring within normal therapeutic dose range
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collateral effects
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(Hypersusceptibility reactions/Collateral effects/side effects/Toxic effects) is unwanted effects occuring above the usual dose range
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toxic effects
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What is the toxic effect of paracetamol?
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liver damage
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What is the collateral effect of aspirin
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damages the lining of the stomach wall and induce small bleeds
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What is the hypersensitivity to penicillin
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skin rash
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Tolerance is due to....
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drug increasing the rate of its own metabolism
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Opioids tolerance is due to...
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adaptive changes in signal transduction that induces a diminish in response
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What is the term for the treatment for more than 1 drug?
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polypharmacy
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give an example of a drug-drug interaction (antagonism)
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Naloxone and heroin on opioid receptors
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give an example of a drug-drug interaction (potentiation)
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aspirin and warfarin
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