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26 Cards in this Set
- Front
- Back
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mechlorethamine
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alkylates guanine, cross links DNA
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cyclophophamide
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alkylates guanine, cross links DNA
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carmustine
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alkylates guanine, cross links DNA
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procarbazine
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alkylates DNA RNA, and protein synthesis, idiopathic mechanism
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cisplatin
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alkylates DNA forming intrastrand and interstrand crosslinks
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methotrexate
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inhibits dihydrofolate reductase (DHFR)
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5-fluorouracil (5-FU)
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inhibits thymidylate synthetase (dTMP)
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gemcitabine
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terminates DNA synth, inhibits ribonucleotide reductase
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vincristine
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inhibits tubulin
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vinblastine
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inhibits tubulin
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paclitaxel- taxol
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stabilizes tubulin
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etoposide
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inhibits topo II
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topotecan
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inhibits topo I
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actinomycin D -dactinomycin (ActD)
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scission of DNA, intercalates DNA
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doxorubicin
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scission of DNA, intercalates DNA
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bleomycin
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bind DNA, generate free radicals, inhibit DNA ligase
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imatinib mesylate
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blocks Bcr-Abl kinase
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trastuzumab
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blocks HER2/neu receptor
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rituximab
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binds CD20 causing lysis
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interferon
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reduces myc transcription, activates a nuclease
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tamoxifen
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estrogen antagonist
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anastrozole
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aromatase inhibitor
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prednisone
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stimulates production of certain proteins
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leuprolide
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gonadotropin releasing hormone
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goserelin
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gonadotropin releasing hormone
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flutamide
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nonsteroidal androgen antagonist
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