• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/5

Click to flip

5 Cards in this Set

  • Front
  • Back
MECHANISM
Alpha1 Receptor Effects
Alpha1 receptor effects are mediated primarily by the trimeric coupling protein Gq. When Gq is activated, the alpha moiety of this protein activates the enzyme phospholipase C, resulting in the release of inositol-1,4,5-trisphosphate (IP 3) and diacylglycerol (DAG) from membrane lipids. Calcium is subsequently released from stores in smooth muscle cells by IP3, and enzymes are activated by DAG. Direct gating of calcium channels may also play a role in increasing intracellular calcium concentration.
MECHANISM
Alpha2 Receptor Effects
Alpha2 receptor activation results in inhibition of adenylyl cyclase via the coupling protein Gi.
MECHANISM
Beta Receptor Effects
Beta receptors (1, 2, and 3) stimulate adenylyl cyclase via the coupling protein Gs, which leads to an increase in cyclic adenosine monophosphate (cAMP) concentration in the cell.
MECHANISM
Dopamine Receptor Effects
Dopamine D1 receptors activate adenylyl cyclase via Gs in neurons and vascular smooth muscle. Dopamine D2 receptors are more important in the brain but probably also play a significant role as presynaptic receptors on peripheral nerves. These receptors act via Gi and reduce the synthesis of cAMP.
5
5