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17 Cards in this Set
- Front
- Back
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Tolerance
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Decreased responsiveness to a drug as a result of repeated drug administration.
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What are the three categories of drug tolerance?
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1. Pharmacodynamic tolerance
2. Metabolic tolerance 3. Tachyphylaxis |
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Pharmacodynamic Tolerance
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The familiar type of tolerance associated with long-term administration of drugs.
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Metabolic Tolerance
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Tolerance resulting from accelerated drug metabolism
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Tachyphylaxis
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Form of tolerance that can be defined as a reduction in drug responsiveness brought on by repeated doing over a short time.
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Placebo
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Preparation that is devoid of intrinsic pharmacologic activity.
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Placebo Effect
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Drug response by psychologic factors and not by biochemical of physiology properties of a drug.
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Bioavailability
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Ability of a drug to reach systemic circulation from its site of administration.
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Pharmacogenetics
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The study of how genes affect individual drug responses.
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Drug Interaction
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A process in which one drug alters the effects of another.
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Dosage adjustments should be made by what?
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Body Surface Area
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Who is more likely to be sensitive to drugs?
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Elderly & Infants
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Kidney failure will result in decreased what?
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Excretion
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If there is kidney failure the nurse will typically give a _______ dose?
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Lower, to prevent toxicity.
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Dose requirements for drugs with narrow therapeutic range are most accurately calculated based on what?
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body surface area
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Aminoglycoside antibiotics are potentially nephrotoxic antibiotics. What assessments and laboratory tests should the nurse monitor when a patient is receiving aminoglycoside antibiotics?
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Vital signs, I & O, weight, changes in mental status, urine specific gravity, blood urea nitrogen (BUN), creatinine, electrolytes, and peak and trough levels of the drug should be monitored.
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A nitroglycerin transdermal patch is ordered to be applied at 0900 and removed at 2100. The patch from the previous day is still in place when the nurse is preparing to administer the 0900 patch. The best action by the nurse is:
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remove the old patch and consult with the prescriber for further directions.
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