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27 Cards in this Set
- Front
- Back
NSAIDS are used for:
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-myalgia -neuralgia -athralgia -alleviation of post op pain -relief from arthritis -treatment of gout and hypertension |
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NSAIDS mechanism of action
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-blocking the chemical activity of the enzyme called cyclooxygenase (COX). Cox-1 has a role in maintaining the GI mucosa. COX 2 |
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Mechanism of action for Aspirin
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-reduced formation of thromboxane a2, a substance that normally promotes platlet aggregation -other NSAIDS lack these antiplatelet effects |
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Acetylsalicylic acid (aspirin-1st)
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-antithrombotic effect: used in the treatmnt of MI and other thromnotic disorders -arthritis, juvi rheumatoid arthritis, lupus, pleurisy, pericarditis -heachache, neuralgia, myalgia, arthalgia |
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Do not give ________ to children or teengagers with flulike symptoms because of the risk of reyes syndrom
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Aspirin |
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Reyes Syndrome
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liver damage coma death |
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Salicylate (aspirin) toxicity-
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tinnitus n/v, diarrhea liver damage reduced renal function sweating, thirst, hyperventilation, hypoglycemia or hyperglycemia metabolic acidosis and respiratory alkalosis |
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Indomethacin (indocin)-
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has analgesic, antirhematic and antipyretic properties -drug given through IV to promote closure of patent ductus arteriosus,a heart defect that sometimes occures in premature infants |
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Ketorolac (toradol)
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-only used short term <5 days because of the effects on kidneys and gi tract bleeding -for moderate-severe pain - PO,IM,IV |
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Celecoxib (celebrex)-
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-indicated use for athritis, acute pain symptons, spondylitis and dysmenorrhea -little effect on platelet function -not to be used in patients with a known sulfa allergy |
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_______ is caused by the overproduction of uric acid and decreased uric acid excretion or both. The deosits of uric acid crystals collect in tissues and joins causing an antiinflammatory response and extreme pain. -hypercemia |
Gout
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Adverse effects of NSAIDS of GI:
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-GI bleeding* -mucosal lesions* *Misoprostol (cytotec) can be used to reduce these dangerous effects |
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Adverse effects of NSAIDs of renal:
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-acute tubular necrosis with renal failure |
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Adverse effects of NSAIDS of cardiovascular:
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-noncardiogenic pulmonary edema
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Allopurinol (zyloprim)
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also used to prevent acute tumor lysis syndroe |
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Colchicine
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-reduces inflammatory response to the deposits of urate crystals in joint tissue -used for short term managment or prevention of gout -may cause short term leukopenia -the more severe adverse effects can include bleedig into the gi or urinary tracts |
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Antigout
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analyze lab results reflecting hematologic, renal and hepatic functioning before initiation of therapy as ordered, especially if long trm use is indicated
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Herbal therapies of Gout:
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adverse side effects:
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slide 68 nursing implications |
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