Pharmacology Ch58 Heavy Metals

Front 1

most of the toxic effects of heavy metals result from this?

Back 1

interaction with sulfhydryl groups of enzymes and regulatory proteins

Front 2

what is a chealator?

Back 2

an organic compound w/ 2 or more electronegative groups that can form stable covalent-coordinate bonds with Cationic metal atoms

Front 3

what drug is used in acute arsenic and mercury poisoning, and lead poisoning if given w/ edetate?

Back 3

Dimercaprol (BAL)

Front 4

what drug is used for ORAL treatment of lead toxicity in children and adults to reduce blood concentration (equally as effective as parenteral EDTA)

Back 4

Succimer

Front 5

IV form of this drug is used in the initial treatment of severe acute poisoning by inorganic mercury or arsenic?

Back 5

Unithiol

Front 6

ORAL Unithiol is an alternative to this drug in the treatment of lead intoxication?

Back 6

Succimer

Front 7

this drug is used to treat copper poisoning and Wilson's disease?

Back 7

Penicillamine

Front 8

this drug is sometimes used as adjunctive therapy in gold, arsenic, and lead intoxication and in Rheumatoid Arthritis?

Back 8

Penicillamine

Front 9

the common adverse effects of this drug are nephrotoxicity w/ proteinuria, PANCYTOPENIA, autoimmune dysfunction, including SLE and hemolytic anemia?

Back 9

Penicillamine

Front 10

this drug is a very effective POLYDENTATE chealator of many divalent and trivalent cations (including Calcium)?

Back 10

Edetate (EDTA)

Front 11

to prevent dangerous hypOcalcemia, this drug is given as the calcium disodium salt?

Back 11

EDTA

Front 12

this drug is a polydentate bacterial product that has an extremely high and selective affinity for IRON and much lower affinity for Aluminum?

Back 12

Deferoxamine

Front 13

what heavy metal produces these signs with acute poisoning: abdominal colic and CNS changes?

Back 13

Lead

Front 14

what heavy metal produces these signs with CHRONIC poisoning: peripheral neuropathy (wrist drop is characteristic), anorexia, anemia, tremor, weight loss, and GI symptoms?

Back 14

Lead

Front 15

chronic poisoning with this heavy metal in children presents with growth retardation, neurocognitive deficits and developmental delay?

Back 15

Lead

Front 16

poisoning with this substance via the skin or lungs results in hallucinations, headache, irritability, convulsions and coma?

Back 16

Organic Lead poisoning (used to be in gas)

Front 17

poisoning with this heavy metsl results in severe GI discomfort, vomiting, "rice water" stools, capillary damage and dehydration and shock?

Back 17

Acute Arsenic poisoning

Front 18

poisoning with this substance may be detected as a sweet garlicky odor in the breath and stools?

Back 18

Arsenic

Front 19

chronic poisoning with this heavy metal is manifested by SKIN changes, HAIR LOSS, bone marrow depression and anemia, and chronic nausea and GI disturbances?

Back 19

Arsenic

Front 20

acute poisoning with this causes chest pain, SOB, nausea and vomiting, kidney damage, gastroenteritis, and CNS damage?

Back 20

Mercury

Front 21

chronic inhalation of this vapor results in diffuse symptoms involving the gums and teeth, GI disturbances, and neurologic and behavioral changes (erethism)?

Back 21

Mercury

Front 22

this drug may redistribute mercury to the CNS and should NOT be used in chronic exposure to elemental mercury?

Back 22

Dimercaprol

Front 23

initial symptoms of this poisoning include vomiting, GI bleeding, lethargy, and gray cyanosis...followed by signs of severe GI necrosis, pneumonitis, jaundice, seizures and coma?

Back 23

Iron

Front 24

what is the chelating agent of choice for Iron poisoning?

Back 24

Deferoxamine

Front 25

chronic excessive intake of this substance may lead to hemosiderosis or hemochromatosis?

Back 25

Iron