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30 Cards in this Set
- Front
- Back
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Bind to the 30s ribosomal subunit, preventing binding of amino acid-charged tRNA to the acceptor site of the ribosome-mRNA complex
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Tetracyclines
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Chloramphenicol is not active against?
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Chlamydiae
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Causes grey baby syndrome and aplastic anemia
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Chloramphenicol:
Decreased rbc's, cyanosis, and cardiovascular collapse. Neonates are deficient in glucuronyltransferase and increase the risk. |
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Chloramphenicol, macrolides, clindamycin and telithromycin all bind to?
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50s ribosome and inhibit transpeptidation
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Backup drug caused by severe infections of Salmonella
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chloramphenicol
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Sometimes used for rickettsial diseases and for infections caused by anaerobes such as Bacteroides fragilis
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Chloramphenicol
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Doxycycline is mainly excreted how?
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In shit
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Resistance to tetracyclines
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efflux pumps for active extrusion
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Currently an alternative to macrolides in the initial txmt of community acquired pneumonia
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Doxycycline:
Mycoplasma pneumoniae and Chlamydiae |
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Alternative drugs to syphilis
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tetracycline
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Drug that causes teeth discoloration and irregularities in bone growth and tooth enamel
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tetracycline
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Used in the txmt of GI ulcers caused by H pylori
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tetracycline
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Used in the prevention of malaria and amebiasis and for lyme disease infections.
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Doxycycline
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Used in the management of patients with ADH secreting tumors, due to its inhibition on the renal actions of ADH
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demeclocycline
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SE of demeclocycline
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enhanced skin sensitivity
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Causes pseudomembraneous colitis
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clindamycin
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Oral antibiotic of choice for moderate inflammatory acne
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Minocycline
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MOA of erythromycin
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Inhibits protein synthesis at the 50s ribosome subunit
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DOC for prophylaxis of endocarditis in valvular disease pts who are allergic to penicillin
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clindamycin
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Used in AIDS pts for P. jiroveci and Toxoplasmosis with TMP/SMX
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clindamycin
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SE include severe hepatotoxicity, visual disturbances, and fainting episodes
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Telithromycin
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Used in MRSA and VRSA
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Linezolid
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Foods containing what may decrease the GI absorption tetracycline
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calcium and mg
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More active than erythromycin against M avium, T gondii, and H pylori
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Clarithromycin
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Resistance to macrolides
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Methylation of binding sites on the 50s ribosomal subunit
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Used in the txmt of C. trachmatis
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Single dose of azithromycin
Week of doxycycline |
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May cause cardiac and CNS toxicity with excessive use of caffeinated beverages
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erythromycin
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Streptogramins are used in?
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Multi-drug resistant streptococci
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Streptogramins that in combo are bacteriocidal
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quinupristin-dalfopristin
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Activity includes penicillin resistant pneumococci, MRSA, VRSA, and E faecium
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Stretogramins:
Quinupristin-dalfopristin |
