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4 Cards in this Set
- Front
- Back
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chemotherapy
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MP regimen:
melphalan (oral)-alkylating agent prednisone VAD regimen: vincristine doxorubicin (adriamycin) desamethasone |
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thalidomide MOA
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sedative w/drawn in 1960s due to teratogenic effects (phocomelia-short arms)
MOA-inhibits angiogenesis and is immunomodulatory inhibits TNF-a, decreases phagocytosis by neutrophils and increases CMI |
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thalidomide
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uses-multiple myeloma, erythema nodosum leprosum
side effects-teratogenic (closely regulated) |
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bortezomib
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MOA-proteasome inhibitor-->decreases NF-kB that promotes cell growth-->cancer cell death
side effects-ND, asthenia, peripheral neuropathy |
