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17 Cards in this Set
- Front
- Back
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CCR5 antagonist
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Moraviroc (MVC) -potent and effective.
But HIV demonstrate mutation to alternative co-receptor target CXCR4, this mutation facilitates T cell destruction by HIV ---> bad prognosis |
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integrase inhibitor
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raltegravir
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fusion inhibitors
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enfuvirtide
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enfuvirtide
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fusion inhibitor- synthetic peptide that binds to gp 41-- may cause hypersensistivity
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drug that binds to gp 41
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enfuvirtide
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NNRTI's
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Nevirapine, Efavinez, Etravirine, Delavirdine NEED
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what drugs don't require phosphorylation
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NNRTI's- but single mutation can cause high grade resistance, they also bind to a different site than NRTI's
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NNRTI - used to prevent vertical transmission but can cause sever hypersensitivity or even severe hepatitis
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Nevirapine,- it has multiple drug interection
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NNRTI that doesn't exhibit cross resistance
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Etravirine
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NNRTI that show mild toxicity but can cause hepatitis and increase transaminases
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Delavirdine
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what group of drugs may cause abnormal carbohydrate and mild metabolism lipodystrophy and osteoporosis
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Protease inhibitors
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a drug that may cause cardiomyopathy
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ZDV - zidovudine
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toxicity of zidovudine
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BM suppression, myelgia, myopathy, mitochindrial toxicity, lypodystrophy, buffulo hump, zanthomas, achne, CNS- headaches, insomnia, peripheral neuropathy
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a drug that competes with AZT for activation
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Stavudine
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a drug that may cause hyperuracemia and gout
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didenosine
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Which NRTI doesn't require activation
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tenofovir
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hypersensitivity of which drug is related to HLAB =5701
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Abacavir
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