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15 Cards in this Set
- Front
- Back
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The statin family of drugs inhibit the first key enzyme involved in cholesterol synthesis, ________________________________ |
hydroxymethylglutaryl-CoA reductase (HMG-CoA reductase)
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There is some indication that very low cholesterol levels may be correlated with an increased risk of __________ |
cancer
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What are the two most common and most efficacious statin drugs? |
simvastatin (Zocor) and atorvastatin (Lipitor)
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Which two statin drugs are associated with high efficacy and more adverse effects? |
Atorvastatin (Lipitor) and rosuvastatin (Crestor) |
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______________ is a statin that is still under patent, is regarded as the most postent reducer of LDL, and has the highest incidence of myopathy. |
rosuvastatin (Crestor) |
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Which statin drug was previously a #1 selling drug? |
atorvastatin (Lipitor) |
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Which statin drug is the most commonly prescribed generic statin? |
simvastatin (Zocor) |
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Cholestin is made from _____________ ___________ (_____ ________), which makes a naturally occurring ________________ similar to the orginal statin drug, ______________ |
Monascus purpureus (red yeast) hydroxymethylglutaryl-CoA reductase inhibitor lovastatin (Mevacor) |
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______________ inhibits absorption of cholesterol through the intestinal wall, thus it works to lower dietary input of cholesterol into the body |
ezetemibe (Zetia)
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Niacin lowers _____________ and _____, and raises ______. |
triglycerides, LDL
HDL
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What are 3 adverse effects of niacin? |
cutaneous flushing, itching and GI upset
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___________ activates lipoprotein lipase, which lowers triglycerides and LDL, and also raises HDL. |
fenofibrate (Tricor) |
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Adverse effects of __________ include risk of gallstone formation,dyspepsia, abdominal pain and diarrhea. |
fenofibrate (Tricor) |
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____________ is an example of a positive surrogate outcome, and a negative clinical outcome. |
torcetrapib |
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What are two non-pharmacological approaches in lowering cholesterol? |
Alcohol aerobic exercise |
