Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
39 Cards in this Set
- Front
- Back
|
Amiodarone is a Class III?
|
antiarrhythmic
|
|
|
Two brands of amiodarone are?
|
Cordarone
Pacerone |
|
|
amiodarone in indicated in what kind of arrhthmias?
|
life-threatening and unresponsive to less toxic agents
|
|
|
The PO form of management of amiodarone is used for the management of what kind of tachyarrythmias?
|
supraventricular
|
|
|
The IV form of amiodarone is used for the management of?
|
ventricular fibrillation/pulseless
ventricular tachycardia after CPR and defib have failed also for other life-threaten- ing tachyarrhythmias |
|
|
Amiodarone's method of action prolongs?
|
action potential and refractory period
|
|
|
Amiodarone's method of action
inhibits? |
blocks both alpha and beta adrenergic receptors of SNS
|
|
|
Amiodarone's MOA slows?
|
sinus rate
|
|
|
Amiodarone's MOA increases?
|
PR and QT intervals
|
|
|
Amiodarone's MOA decreases?
|
<peripheral vascular resistance
(vasodilation)> |
|
|
The THERAPEUTIC EFFECTS of amiodarone is?
|
suppression of arrhythmias
|
|
|
Amiodarone is contraindicated with severe?
|
sinus node dysrhythmia
|
|
|
Amiodarone is contraindicated in what kind of blocks?
|
2nd and 3rd-degree AV blocks
|
|
|
Amiodarone is contraindicated in bradycardia because?
|
it has caused syncope unless a pacemaker is in place
|
|
|
Amiodarone interactions...increase blood levels and may lead to toxicity from which drug?
|
digoxin (decreased dose of digoxin by 50%)
|
|
|
Amiodarone interactions...increase blood levels and may lead to toxicity from?
|
other class I antiarrhythmics
ex: quinidine procainamide mexiletine lidocaine flecainide |
|
|
Amiodarone interactions...
increase blood levels of? |
cyclosporine
dextromethorphan methotrexate phenytoin theophylline |
|
|
Amiodarone
Phenytoin does what to amiodarone levels? |
decreases
|
|
|
Amiodarone does what to the activity of warfarin?
|
increases
|
|
|
Amiodarone increases the risk of?
|
bradyarrhythmias
sinus arrest AV heart block with beta blockers or CCBs |
|
|
Cholestyramine may do what to amiodarone blood levels?
|
decrease
|
|
|
Cimetidine nd ritonavir does what to amiodarone blood levels?
|
increases
|
|
|
What should be monitored continuously with amiodarone?
|
ECG
report bradycardia |
|
|
What is the most serious adverse effect which can be fatal in about 10% of amiodarone patients?
hint: toxicity |
PULMONARY TOXICITY
ex: rales/crackles decreased breath sounds pleuritic friction rub fatigue dyspnea cough pleuritic pain fever these symptoms can damage alveoli causing possible pulmonary fibrosis |
|
|
With IV amiodarone, assess patient for signs and symptoms of?
|
ARDS...report dyspnea, tachypnea, or rales/crackles promptly
|
|
|
With IV amiodarone, monitor blood pressure frequently. What condition usually occurs during first several hours?
|
hypotension...if it occurs, slow rate of infusion
|
|
|
What vision problems may occur with IV amiodarone?
|
photophobia
halos around lights decreased acuity possible permanent loss of vision (at home: patient may experience photosensitivity...use protective clothing and sunblock) |
|
|
Signs of hypothyroidism may occur with IV amiodarone. What are the symptoms?
|
lethargy
weight gain edema of hands, feet, and periorbital region cool, pale skin |
|
|
Signs of hyperthyroidism may occur with IV amiodarone. What are the symptoms?
|
tachycardia
weight loss nervousness sensitivity to heat insomnia warm, flushed, moist skin |
|
|
With IV amiodarone, monitor which functions?
|
liver function
thyroid function |
|
|
What other lab tests should be evaluated with amiodarone?
|
AST
ALT alkaline phosphatase |
|
|
Teaching. If a dose of amiodarone is missed?
|
don't take it at all
|
|
|
Teaching. Photosensitivity while taking amiodarone may occur. Tell patient?
|
wear sunscreen
wear protective clothing reaction may occur if patient wears thin clothing or sits near window |
|
|
Teaching. Prolonged use of amiodarone may cause what to happen to face, neck, arms?
|
bluish discoloration...reversible and will disappear over several months
|
|
|
Teaching. What condition may appear in males taking amiodarone?
|
epididymitis which is pain and swelling in scrotum
|
|
|
What does amiodarone have in it's chemical structure that can cause hyper or hypothyroidism?
|
iodine
|
|
|
What does amiodarone do to the eyes with prolonged use that causes visual disturbances?
|
causes corneal microdeposits which results in visual halos, photophobia, and dry eyes in everyone taking it more than 6 months
|
|
|
Ammiodarone can treat dysrhthmias, and can also?
|
provoke dysrhythmias
avoid use with CHF |
|
|
Amiodarone is very lipophilic or fat loving...which means?
|
it accumulates slowly in body tissues and can reach high levels in FAT, muscle, liver, spleen, lungs
|
