Pharmacology Biom1008 - Anti-Infective Drugs

Front 1

Bactericidal Drugs ______________.

Back 1

Kill Bacteria

Front 2

Name a bactericidal drug.

Back 2

Penacillin

Front 3

Bacteriostatic Drugs ______________.

Back 3

Inhibit Reproduction

Front 4

Name a bacteriostatic drug.

Back 4

Tetracycline

Front 5

What does MIC stand for?

Back 5

Minimum Inhibitory Concentration

Front 6

What does MBC stand for?

Back 6

Minimal Bactericidal Concentration

Front 7

Low values of Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) indicate potency. True or false.

Back 7

True

Front 8

Post-antibiotic Effect is caused by the persistence of the antibiotic at its binding sites and that bacteria need to synthesize new proteins before growth can continue. True or False?

Back 8

True

Front 9

Class I antibiotics ultimately target what process?

Back 9

ATP generation

Front 10

Class II antibiotics ultimately target what process?

Back 10

Growth

Front 11

Class III antibiotics ultimately target what process?

Back 11

Assembly of Macromolecules (DNA, peptidoglycan etc.)

Front 12

Sulphonamides are antibiotics which inhibiting nucleic acid synthesis. True or False?

Back 12

True

Front 13

What type of antibiotic inhibits nucleic acid synthesis?

Back 13

Sulphonamides

Front 14

b-lactam penicillins are antibiotics that inhibit cell wall synthesis. True or False?

Back 14

True

Front 15

Name an antibiotic that inhibits cell wall synthesis.

Back 15

b-lactam penicillins (e.g amoxicillin)

Front 16

b-lactam antibiotics interfere with the synthesis of the bacterial cell wall peptidoglycan, by covalently binding to the bacterial transpeptidation enzyme (penicillin binding protein) and preventing cross linkage between layers. True or False

Back 16

True

Front 17

How does Cycloserine affect the addition of residues to peptide side chains in bacteria?

Back 17

Inhibits

Front 18

What prevents the release from the carrier in bacteria cell wall synthesis?

Back 18

Vancomycin

Front 19

What prevents recycling of the lipid carrier in bacteria cell wall synthesis?

Back 19

Bacitracin

Front 20

Aminoglycosides (such as gentamycin and streptomycin) are anti-biotics which target protein synthesis in bacteria. True or False?

Back 20

True

Front 21

Tetracyclines (such as oxytetracycline and doxycycline) are anti-biotics which target protein synthesis in bacteria. True or False?

Back 21

True

Front 22

What is the purpose of Adjunctive Drugs?

Back 22

Increase efficacy of antibiotics.

Front 23

Probenecid is an Adjunctive Drugs which inhibits ___________.

Back 23

penicillin excretion

Front 24

Clavulanic acid is an Adjunctive Drugs which is a _______________ inhibitor.

Back 24

penicillinase

Front 25

Cilastin is an Adjunctive Drugs which prevents __________________________ of imipenem

Back 25

Enzymatic Degredation

Front 26

Over use of antimicrobial agents can result in _________________.

Back 26

Resistance (MRSA)

Front 27

Adverse effects such as hypersensitivity and anaphylaxis can occur with over using antibiotics. True or False?

Back 27

True

Front 28

HIV gp120 coat protein doesn't bind to CD4 receptor on host cell. True or False?

Back 28

False

Front 29

CD4 is a Receptor Tyrosine Kinase. True or False?

Back 29

True

Front 30

Give 2 examples of Nucleoside analogue reverse transcriptase inhibitors (NRTIs) anti-viral drugs.

Back 30

Zidovudine, Abacavir

Front 31

Give 2 examples of Non-nucleoside reverse transcriptase inhibitors (NNRTIs) anti-viral drugs.

Back 31

Nevirapine, Viramune®

Front 32

Give 2 examples of Protease Inhibitors used as anti-viral drugs.

Back 32

Saquinavir, Invirase®

Front 33

Helminths include Nematodes (roundworms), trematodes (flukes) and cestodes (tapeworms). True or False?

Back 33

True

Front 34

What anti-helminthic agent disrupts calcium homeostasis by binding to calcium channels which stimulates more calcium entry leading to contraction and paralysis? Piperazine, Praziquantal, Levamisole, Ivermectin or Benzimidalzoles?

Back 34

Praziquantal

Front 35

What anti-helminthic agent Inhibits b- tubulin microtubule dependent functions such as glucose uptake? Piperazine, Praziquantal, Levamisole, Ivermectin or Benzimidalzoles?

Back 35

Benzimidalzoles

Front 36

What anti-helminthic agent Inhibits neuromuscular transmission by Mimicking GABA at GABA Chloride channels causing paralysis? Piperazine, Praziquantal, Levamisole, Ivermectin or Benzimidalzoles?

Back 36

Piperazine

Front 37

What anti-helminthic agent causes motor paralysis
by opening glutamate gated chloride channel? Piperazine, Praziquantal, Levamisole, Ivermectin or Benzimidalzoles?

Back 37

Ivermectin

Front 38

What anti-helminthic agent causes stimulation and blockade of neuromuscular junctions causing paralysed worms to be expelled in faeces? Piperazine, Praziquantal, Levamisole, Ivermectin or Benzimidalzoles?

Back 38

Levamisole

Front 39

What anti-fungal is tubulin-binding and prevents division? Echinocandin B, Azoles, Terbinafine, Flucytosine, Griseofulvin, Amphotericin or Nystatin?

Back 39

Griseofulvin

Front 40

What anti-fungal inhibits 1-3-b-glucan synthesis? Echinocandin B, Azoles, Terbinafine, Flucytosine, Griseofulvin, Amphotericin or Nystatin?

Back 40

Echinocandin B

Front 41

What anti-fungal inhibits squalene epoxidase, ergosterol synthesis? Echinocandin B, Azoles, Terbinafine, Flucytosine, Griseofulvin, Amphotericin or Nystatin?

Back 41

Terbinafine

Front 42

What anti-fungal inhibits cytochrome P450-3A, lanosine 14a demethylase - membrane wall? Echinocandin B, Azoles, Terbinafine, Flucytosine, Griseofulvin, Amphotericin or Nystatin?

Back 42

Azoles

Front 43

What anti-fungal disrupts DNA synthesis? Echinocandin B, Azoles, Terbinafine, Flucytosine, Griseofulvin, Amphotericin or Nystatin?

Back 43

Flucytosine

Front 44

What anti-fungal binds to ergosterol- alters cell membrane permeability? Echinocandin B, Azoles, Terbinafine, Flucytosine, Griseofulvin, Amphotericin or Nystatin?

Back 44

Nystatin

Front 45

What anti-fungal binds to ergosterol - alters cell membrane permeability? Echinocandin B, Azoles, Terbinafine, Flucytosine, Griseofulvin, Amphotericin or Nystatin?

Back 45

Amphotericin

Front 46

What anti-protozoal agent inhibits or antagonises folic acid metabolism? Primethamine, Atovaquone, Azithromycin, Chloroquine or Artemisinin?

Back 46

Primethamine

Front 47

What anti-protozoal agent inhibits calcium dependent ATPase? Primethamine, Atovaquone, Azithromycin, Chloroquine or Artemisinin?

Back 47

Artemisinin

Front 48

What anti-protozoal agent blocks protein synthesis? Primethamine, Atovaquone, Azithromycin, Chloroquine or Artemisinin?

Back 48

Azithromycin

Front 49

What anti-protozoal agent blocks the electron transport chain? Primethamine, Atovaquone, Azithromycin, Chloroquine or Artemisinin?

Back 49

Atovaquone

Front 50

What anti-protozoal agent forms a digestive vacuole to stop detoxification of Haem? Primethamine, Atovaquone, Azithromycin, Chloroquine or Artemisinin?

Back 50

Chloroquine