Pharmacology Autonomics Part 1

Front 1

Muscarinic receptors are found where in the ANS?

Back 1

ALL Post-ganglionic parasym
Post-gang. sympathetic only at sweat glands and some BV's

Front 2

The ANS controls mosly what tissues?

Back 2

Heart, smooth muscle, glands and also the Adrenal Medulla

Front 3

Nicotinic Receptors are found where in the ANS?

Back 3

ALL Pre-gang (both symp and para symp)
Also can be found in SNS at the NMJ

Front 4

What are the two classes of receptors in the ANS and what NT's are the associated with

Back 4

Cholinergic- ACh
Adrenergic- Norepi/epi

Front 5

What are the two types of cholinergic receptors?

Back 5

Nicotinic
Muscarinic

Front 6

Which cases are "special" in that the do not have dual innervation like all other organs/tissues?

Back 6

Adrenal Medulla
Blood Vessles
Sweat Glands

Front 7

Parasympathetics of EYE:
__muscle-miosis
__muscle-focus for near vision

Back 7

Circualr/Sphincter
Ciliary

Front 8

Sypathetic of eye
__ muscle- alpha adrenergic stimulation results in contraction/mydriasis
__muscle-beta adrenergic INHIBITION leads to dcreased aqueous humor

Back 8

Radial
Ciliary

Front 9

Give example of:
Dual innercation to same cell:__
Dual innervation to different cells:___
Single innervatoin__

Back 9

SA Node

Eye

BV's

Front 10

Which of the following have Sympathetic system as the dominant tone (may be more than 1): Arterioles, Veins, Heart, Iris, Ciliary Muscle, GI tract, Bladder, Salivary Glands, Sweat glands

Back 10

Arterioles
Veins
Sweat glands

Front 11

List the Cholinomimetic drugs:

Back 11

Memory device:
Meth Beth Ach all took a Pilot Car to see Cholin
(methacholine, bethanechol, Acetylcholine, Pilocarpine, carbachol are Cholinomimetic)

Front 12

Drug for Xerostomia

Back 12

Pilocarpine

Front 13

Drug used to diagnose airway sensitivity

Back 13

Methycholine

Front 14

Used to simulate muscarinic receptors in eye (useful in glaucoma), intestine and bladder

Back 14

Carbachol

Front 15

2 Cholinomimetics that are resistant to AChE and pseoesterase and therefore last longer than ACh

Back 15

Carbachol, Bethanechol

Front 16

Used to stimulate bladder and intestine

Back 16

Bethanechol

Front 17

Drug approved to treat xerostomia in pt's with Sjogren's

Back 17

Cevimeline

Front 18

Side effects of Cholinomimetic drugs and muscarinic agonists

Back 18

Sweating, flushing, salivation, constriction of bronchi, nausea, vomiting, miosis, lacrimation

Front 19

Caution use of Cholinomimetic drugs in:

Back 19

Hyperthyroidism, Asthma, GI ulcers

Front 20

Drugs to treat glaucoma

Back 20

Echothiophate
Physostigmine

Front 21

Drugs used to Treat Myasthenia Gravis

Back 21

Neostigmine
Pyridostigmine
Ambenonium

Front 22

Drugs used to treat Alzheimers

Back 22

Tacrine, Donepezil, Galantagmine, rivastigmine
Al's Done Galavanting on the Tac River

Front 23

2 drugs that reverse block by nondepolarizing NMJ blockers:

Back 23

Neostigmine
Pyridostigmine

Front 24

Nerve gas

Back 24

Sarin, tabun, soman

Front 25

Insecticide

Back 25

Carbamates, malathion, parthion

Front 26

List the Reversible AChE inhibitors

Back 26

Physostigmine
Neostibmine
Pyridostigmine
(phy, py, neo-mines)

Front 27

List the Irreversible AChe Inhibitors

Back 27

Organophosphates- Echothiophate
Malathion
Mal-Ech-O

Front 28

Antidote for atropine poisoning

Back 28

Physostigmine

Front 29

Only reversible AChE inhibitor that is not charged so can get into places others can't (like the CNS)

Back 29

Physostigmine

Front 30

Which insecticide is less harmful to humans:
Malathion, parathion, paraoxon, echothiophate

Back 30

Malathion

Front 31

Antidote for poisoning by AChE inhibitors-both irreversible and reversible

Back 31

Reversible-atropine
Orangophosphates-Atropine+ paralidoxime (2-PAM)

Front 32

Atropine or Scopolamine:
Sometimes used to produce mydriasis and cycloplegia

Back 32

Atropine

Front 33

Atropine or Scopolamine:
May be used to provide pre-anesthetic sedation

Back 33

Scopolamine

Front 34

Atropine or Scopolamine:
Used to inhibit salivary secretion

Back 34

Scopolamine

Front 35

Atropine or Scopolamine:
Sometimes used to relive bradycardia in MI pts

Back 35

Atropoine

Front 36

Atropine or Scopolamine:
Used to reduce or prevent muscarinic side effects, increase cholinergic effects at other sites, and to counteract the toxic effect of AChE Inhibitors

Back 36

Atropine

Front 37

Atropine or Scopolamine are well absorbed by __ and half life is about __

Back 37

Mouth
13-38 hours

Front 38

2 drugs used as mydriatic-cycloplegic because of short duration

Back 38

Homatropine
Tropicamide

Front 39

3 drugs that affect the GI tract
2 are antispasmotic
1 is used in IBS
Are these drugs used often?

Back 39

Antispasmotic: Glycopyrrolate and Propantheline
Dicyclomine
No, too many bad side effects

Front 40

Drug used in lung to treat astma and COPD, has a charge so it will stay in lung

Back 40

Ipratropium

Front 41

Drug used to reduce extrapyramidal side effects of the antipsychotic drugs

Back 41

Benztropine

Front 42

Drugs used to treat overactive bladder

Back 42

Oxybutynin
Flavoxate
Tolterodine
Ox bladder Flavors To

Front 43

Antidote for antimuscarinic drugs is ___

Back 43

Physostimine

Front 44

Contraindications for use of Antimuscarinic drugs:

Back 44

Prostate hypertrophy
Glaucoma

Front 45

Drugs that stimulate the Nn receptor as an agonist

Back 45

Nicotine-actually stimulates both Nn and NM receptors

Front 46

Drugs that stimulate the Nn as an antagonist

Back 46

Nicotine
Hexamethonium
Mecamylamine

Front 47

NMJ bolockers- list the Depolairzings drugs:

Back 47

Succinylcholine- this will affect both Nn and Nm receptors

Front 48

What are the uses of NMJ blockers?

Back 48

Used in hospital setting only during surgery

Front 49

Side effects of Depolarizing NMJ bockers (Succinylcholine)

Back 49

Muscle soreness, brief bradycardia then possibly tachycardia and hypertension, increase in intraocular pressure, Loss of muscular K+ (long term use)

Front 50

Which are reversed by AChE inhibitors: Depolarizing or Non-depolarizing

Back 50

Non-depolarizing

Front 51

Non-depolarizing NMJ blockers are selective for which receptors

Back 51

Nm

Front 52

Atropine or Scopolamine:
Sometimes used to produce mydriasis and cycloplegia

Back 52

Atropine

Front 53

Atropine or Scopolamine:
May be used to provide pre-anesthetic sedation

Back 53

Scopolamine

Front 54

Atropine or Scopolamine:
Used to inhibit salivary secretion

Back 54

Scopolamine

Front 55

Atropine or Scopolamine:
Sometimes used to relive bradycardia in MI pts

Back 55

Atropoine

Front 56

Atropine or Scopolamine:
Used to reduce or prevent muscarinic side effects, increase cholinergic effects at other sites, and to counteract the toxic effect of AChE Inhibitors

Back 56

Atropine

Front 57

Non-dep. NMJ blockers are increased by

Back 57

Several anesthetics
Aminoclycosides
Lidocaine
Calcium Channel Blockers

Front 58

List the Non-depolarizing blockers

Back 58

D-tubocurarine
Pancuronium
Atracurium
Vecuronium
Will all have "cur"

Front 59

Non-depol. NMJ blockers that relsease histamine

Back 59

D-tubocurarine
Atracurium
Mivacurium

Front 60

__ acts like succinylcholine without inital twitching/muscle soreness

Back 60

Mivacurium

Front 61

3 Drugs metabloized by liver (steroids)

Back 61

Pancuronium
Pipercuronium
Rocuronium

Front 62

__-drug that acts on muscle directly by inhibiting Ca+ release from SR

Back 62

Dantrolene