Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Tetracyclines: What are the 3 groups?
|
Group 1: Chlortetracycline, Oxytetracycline
Group 2: Demeclocycline, Methacycline Group 3: Doxycycline, Minocycline |
|
|
Tetracyclines:
MOA/PD? Resistance? |
MOA/PD:
(1) Bacteriostatic, Bind 30S (2) Prevent access of aminoacyl tRNA to A site (3) Enter cell by energy dependent transport and passive diffusion through porin Resistance: Cross resistance seen in all tetracyclines (1) Decreased influx or pump out (2) Decreased ribosome access due to "protection protein" (3) Increased enzymatic inactivation |
|
|
Tetracyclines: DI?
|
(1) Divalent or trivalent cations that contain bismuth and aluminum chelate tetracyclines & reduce absorption [not for long acting doxy- & mino-cycline]
(2) ANATGONISM w/ penicillins in pneumococcal meningits [tetracyclines ALONE are better] (3) With DIURETICS increases BUN (4) POTENTIATE COUMARIN type anticoagulants via unknown mechanism |
|
|
Tetracylcines:
DOC? Spectrum? Alternative to penicillin in? Drug effective in ETEC? |
DOC:
(1) Mycoplasma pneumoniae [1st along w/ macrolides] Spectrum: Use has declined drastically b/c of resistance (1) Chlamydiae including pneumoniae, lymphogranuloma venereum, PID [except trachoma T.C is C/I -->Azithromycin or Sulfacetamide] (2) Propionibacteria (3) Brucella, Borrelia, Cholera, Nocardia, & Turlaremia Alternative to syphillis in: Syphilis in non-pregnant w/ penicillin allergy Drug effective in ETEC: Doxycycline |
|
|
Tetracyclines:
Route? Distribution? Excretion? |
Route: Food impairs absorption of tetracyclines [divalent ions chelate] except for group III [doxycycline & minocycline]
Distribution: (1) Minocycline good CNS compared to rest (2) All concentrated in RES [liver, spleen, teeth, tumors w/ Ca2+, etc] Excretion: All renal except doxycycline [biliary], Excreted in milk [can affect suckling infant] |
|
|
Tetracycline: Best CNS distribution?
|
Minocycline
|
|
|
Tetracycline: Excreted in bile?
|
Doxycycline
|
|
|
Tetracyclines:
AE? Vestibular toxicity drug? |
(1) Pseudomembranous colitis, Superinfection, Nephrotoxic, Hepatotoxic
(2) Fanconi-like syndrome [degraded and outdated tetracyclines] (3) Staining of teeth [C/I in pregnancy & < 8yo] (4) Photosensitivity (5) Irritation in local admin, Hypersensitivity, Benign reversible increase in ICP, Long term use associated w/ leucocytosis, atypical leukocytes, etc. Vestibular toxicity: Monocycline only |
|
|
Tetracyclines: Used in treatment of leprocy?
|
Minocycline
|
