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16 Cards in this Set

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What is an antilipemic?
substance that maintains normal blood lipid levels...
treats hyperlipidemia
What is the most potent group of antilipemics?
HMG-COA Reductase inhibitors
A brand name antilipemic is?
Lipitor
What is antilipemic Lipitor used for?
primarily used to lower total and LDL cholesterol as well as triglycerides...can increase HDL
Atorvastatin is most effective in lowering?
triglycerides
An antilipemic is usually identified with the ending?
-statin
How long does it take for medication to become effective?
6-8 weeks
MOA for atorvastatin (Lipitor) is?
decreases blood cholesterol by decreasing rate of cholesterol production...what relationship does the liver and HMG-CoA have?

decreases cholesterol production...when decreased amounts of cholesterol are being produced, how does the liver respond?

steroids
bile acids
cell membranes
liver requires HMG-CoA reductase to PRODUCE cholesterol...statins inhibit HMG-CoA reductase...what does this do?

liver increases number of LDL receptors in order to augment the recycling of LDL from CIRCULATION back into liver, where its needed for synthesis of other needed substances such as (3)?
What is HMG-CoA?
rate-limiting enzyme in the reactions needd to make cholesterol
How does atorvastatin treat hyperlipidemia?

HDL cholesterol level is increased by 2% to 15%
reduces plasma concentration of LDL by 30% to 40%...how is HDL affected?
Most common side effects of atorvastatin (Lipitor) are?
headache
GI
constipation
cramps
diarrheaa
nausea
bowel function changes
skin rashes
A less common side effect of atorvastatin is?
myopathy (muscle pain)
Which enzymes may go up when taking HMG inhibitors?
liver enzymes
Coadministration of HMG inhibitors with:
erythromycin
gemfibrozil (Lopid) a fibric
acid dirivative and used to
as an antilipemic
niacin
has been observed to rarely lead to development of?
rhabdomyolysis
Atorvastatin can increase what 3 things?
SGOT levels
activated clotting time
thrombocytopenia
<Why is Lipitor beneficial to patients with unstable angina?>
<prevents future "events">