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35 Cards in this Set
- Front
- Back
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What are the 2 types of cholinesterase?
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acetylcholinesterase
butyrylcholinesterase |
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Which is a true cholinesterase (acetylcholinesterase/butyrylcholinesterase)
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acetylcholinesterase
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Which has limited substrate? (acetylcholinesterase/butyrylcholinesterase)
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acetylcholinesterase
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which is a membrane bound form found in the basement membrane of synaptic cleft in cholinergic synapses? (acetylcholinesterase/butyrylcholinesterase)
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acetylcholinesterase
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Which is found in erythrocyte? (acetylcholinesterase/butyrylcholinesterase)
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acetylcholinesterase
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which is in a soluble form found in cholinergic nerve terminals (acetylcholinesterase/butyrylcholinesterase)
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acetylcholinesterase
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What enzyme joins acetyl with choline to produce acetylcholinesterase
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Choline acetyltransferase
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Which is a pseudocholinesterase (acetylcholinesterase/butyrylcholinesterase)
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butyrylcholinesterase
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Which is a membrane bound form found in liver, skin, brain and GI tract? (acetylcholinesterase/butyrylcholinesterase)
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butyrylcholinesterase
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Which is soluble form found in plasma? (acetylcholinesterase/butyrylcholinesterase)
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butyrylcholinesterase
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Cholinesterases are s_____ h________
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serine hydrolases
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What are the 3 groups of peripherally acting anticholinesterase?
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Short acting
Intermediate Irreversible |
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Edrophonium is a (Short acting/Intermediate/Irreversible) and only binds to anionic site
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short acting
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What is edrophonium used in the diagnosis of?
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Myosthenia gravis
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Neostigmine, pyridostigmine and physostigmine are (Short acting/Intermediate/Irreversible)
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intermediate
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When neostigmine acts the ________ group is transferred to serine OH and hydrolysis of ______ serine is slow
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carbonyl
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Dyflos, parathion, Sabun and Sarin are (Short acting/Intermediate/Irreversible)
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Irreversible
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Dyflos, parathion, Sabun and Sarin are also o___________ compounds
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organophosphorus
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What is the mechanism for Dyflos, parathion, Sabun and Sarin
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no hydrolysis of phosphorylated enzyme
no interaction with aniotic site |
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The effect of anticholinesterase drugs on neuromuscular junction is an (increase/decrease) in muscle tension. High doses can cause _______ due to depolarisation block
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increase
paralysis |
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The effect of anticholinesterase drugs on the autonomic is an (increase/decrease) in salivation, lacrimation and bronchial secretion
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increase
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The effect of anticholinesterase drugs on the autonomic is an (increase/decrease) in G.I motility
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increase
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The effect of anticholinesterase drugs on the autonomic is an (increase/decrease) in heart rate
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decrease hypotension
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The effect of anticholinesterase drugs on the autonomic is also m________
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miosis (constriction of pupil)
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The effect of anticholinesterase drugs on the CNS is....
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excitement
convulsion respiratory failure |
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The effect of anticholinesterase drugs on neurotoxicity is.......
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loss of sensory function
muscle weakness (demylination of peripheral nerves) |
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What is the non-clinical uses of anticholinesterase drug?
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Insecticides
Nerve gases - antidote |
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What is used for anaesthesia? (Neostigmine/tubuocurarine/physostigmine/physostigmine)
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neostigmine
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What is used for the reversal of action of competitive neuromuscular blocking agents? (Neostigmine/tubuocurarine/physostigmine/physostigmine)
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tubuocurarine
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What is used for atropine poisoning? (Neostigmine/tubuocurarine/physostigmine/physostigmine)
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physostigmine
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What is used for glaucoma? (Neostigmine/tubuocurarine/physostigmine/physostigmine)
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physostigmine
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What is used to treat myasthenia gravis? (Neostigmine/tubuocurarine/physostigmine/pyridostigmine)
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neostigmine and pyridostigmine
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In myasthenia gravis the antibodies bind to which receptors?
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nicotinic receptor
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What is used in the diagnosis of myasthenia gravis?
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edrophonium
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What is myasthenia gravis?
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an autoimmune disease
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