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20 Cards in this Set
- Front
- Back
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What is the mechanism of action of penicillins?
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- inhibiting formation of peptidoglycan cross-links in the bacterial cell wall
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What are the four classes of penicillins?
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-natural
- penicillinase-resistant - aminopenicillins -extended-spectrum |
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What functional group of penicillin binds to enzyme DD transpeptidase?
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- Beta lactam
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What is trade name of penicillin G the natural penicillin?
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- trade name: pfizerpen
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What is the dose and ROA of pfizerpen?
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- 20-30 million units/d
- IV or intramuscular |
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What is the trade name of the penicillinase-resistant penicillin cloxacillin sodium?
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- Cloxapen
- Tegopen |
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What is the dosage and ROA of cloxacillin sodium?
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- 250-500mg q6h
- oral |
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What are the trade names of the aminopenicillin amoxicillin?
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- amoxil
-trimox -wymox |
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What is the dosage and ROA of amoxicillin?
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- 250-500 mg q8h or 875 twice daily
- Oral |
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What are the trade names of the aninopenicillin named ampicillin?
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- omnipen
- principen - totacillin |
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What is the dosage and ROA of ampicillin?
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- 250 - 500 mg q6h
- Oral |
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What are the trade names of the extended spectrum penicillin mexlocillin sodium?
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- mezlin
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What is the dosage and ROA of mezlocillin sodium?
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- 200 -300mg/kg/d in 4-6 doses
- intra muscular, IV |
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What is a extended spectrum penicillin?
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-mezlocillin sodium
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What are two aminopenicillins?
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- amoxicillin
- ampicillin |
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What is a semisympathetic penicillin, or pencillinase-resistant penicillin?
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- cloxacillin sodium
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What is the name of a natural penicillin?
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- penicillin G
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What is penicillin G the original penicillin used to treat still? (7)
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- UTIs
- gonorrhea -syphilis - septicemia - meningitis - pneumonia - respiratory infections |
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What are common adverse effects of penicillin?
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- nausea, vomiting, diarrhea, black tongue
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What is the serious adverse effects of penicillin?
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- neurotoxicity in very high doses
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