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6 Cards in this Set

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Penicillins

Mode of action
-inhibit penicillin binding proteins
-PBPs are necessary for synthesizing mucopeptide
-this activates cell wall autolytic enzymes
-end result is cell lysis
Penicillins

Effect
Bactericidal
Lactamase Resistant Penicillins
Cloxacillin
Dicloxacillin
Oxacillin
Methicillin
Amoxi/Clavulanic Acid
Timentin=Ticar+Clavulanate
Impenem
Meropenem
Penicillins
Properties
Vd < 0.6 (not good)
weak acid
polar
eliminated unchanged in urine
half life = 1-2 hrs
Potentiated Penicillins
these have clavulanic acid which binds irreversibly to lactamases, preventing hydrolysis of penicillin rings
-sulbactam and tazobactam are others
Penicillin + Aminoglycosides
-synergistic relationship esp with R enterococci
-can inactivate ea other if mixed in same syringe