Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
Penicillins
Mode of action |
-inhibit penicillin binding proteins
-PBPs are necessary for synthesizing mucopeptide -this activates cell wall autolytic enzymes -end result is cell lysis |
|
Penicillins
Effect |
Bactericidal
|
|
Lactamase Resistant Penicillins
|
Cloxacillin
Dicloxacillin Oxacillin Methicillin Amoxi/Clavulanic Acid Timentin=Ticar+Clavulanate Impenem Meropenem |
|
Penicillins
Properties |
Vd < 0.6 (not good)
weak acid polar eliminated unchanged in urine half life = 1-2 hrs |
|
Potentiated Penicillins
|
these have clavulanic acid which binds irreversibly to lactamases, preventing hydrolysis of penicillin rings
-sulbactam and tazobactam are others |
|
Penicillin + Aminoglycosides
|
-synergistic relationship esp with R enterococci
-can inactivate ea other if mixed in same syringe |