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18 Cards in this Set

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Cefuroxime sodium goes under the names?
Ceftin
Zinacef

second-generation cephalosporin
Cefuroxime is used for?
surgical prophylaxis
UTIs
otitis media
respiratory tract infections
meningitis
MOA of cefuroxime?
bind to bacterial cell wall membrane, causing cell death
Therapeutic effects of cefuroxime?
bactericidal action
Works against the following
bacteria?
Haemophilus influenzae
Escherichia coli
Klebsiella pneumoniae
Neisseria gonorhoeae
Proteus
Moraxella catarrhalis
(not active against methicillin-resistant staphylococci or enerococci)
Assess patient for infection at beginning and during therapy. Symptoms are?
vital signs
appearance of wound
sputum
urine
stool
WBC
Before initiating therapy, obtain a history to determine previous use of and reactions to which antibiotics?
penicillins
cephalosporins
Observe patient for signs and symptoms anaphylaxis...signs are?
rash
pruritis
laryngeal edema
wheezing
(d/c meds if these conditions occur...keep epinephrine, an antihistamine, and resuscitative equipment close by in event of anaphylactic reaction)
Assess patient for renal?

seizures
myoclonus
encephalopathy

also assess for nephrotoxicity
dysfunction and adjust dose accordingly....monitor for
dose-related adverse CNS events which include?
May cause positive results for which test?
Coombs'...esp in patients receiving high doses or in neonates whose mothers were given cephalosporins before delivery
Monitor prothrombin time and assess patient for bleeding...what should be checked for bleeding?
guaiac stools
hematuria
bleeding gums
ecchymosis
Cefuroxime may also cause false-negative?
blood glucose results with ferricyanide tests...use glucose enzymatic or hexokinase tests to determine blood glucose
May cause increases serum? (7)
AST
ALT
alkaline phosphatase
bilirubin
LDH
BUN
creatinine
With PO administration, administer around the clock. To decrease GI disturbanc, may be administered on?
full or empty stomach...shake oral suspension well
Don't crush tablets...doesn't have to be taken with meals, but take at evenly spaced times and finish completely...however suspension should be taken with food...shake well...don't mix tabs with suspension
okay
Advise patient to report signs of?

furry overgrowth on tongue
vaginal itching
discharge
loose or foul-smelling stools

also report allergies
superinfection...signs are?
Instruct patient to notify hcp if fever and diarrhea develop, esp if stool contains?
blood
pus
mucus...
don't treat diarrhea without consulting hcp
Clinical response to therapy can be evaluated by?
resolution of signs and
symptoms of infection
length of time for complete
resolution depends on
the organism and site of
infection
decreased incidence of
infection when used for
prophylaxis