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16 Cards in this Set
- Front
- Back
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The MOA Amphotericin B
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bind to ergosterol, then forms pores in the fungal membrane. Fungicidal
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The ADR of Amphotericin B
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*renal toxicity
hypotension arrhythmias fever anemia phlebitis |
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Major uses of Amphotericin B
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Generally used only in severe systemic infections
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Major uses of Nystatin
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Topical Candida infections (oral thrush, vaginosis, etc
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MOA of Imidazoles/Triazoles (azoles):
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-Block SYNTHESIS of ergosterol (stop conversion of lanosterol to ergosterol).
-How they do this is to block the CYP450 system in fungi (note some cross-reaction with human CYP system). -Fungicidal or fungistatic depending on concentration |
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Use of Fluconazole
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meningeal fungal infections (generally Cryptococcus)
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MoA Terbinafine
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Blocks synthesis of ergosterol but at a different point than azoles (stops conversion of squalene to lanosterol). Fungicidal
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Use of Terbinafine
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dermatophyte infections (generally ones resistant to topical treatment), in particular deep nail infections (onychomycoses).
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MoA Echinocandins
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block synthesis of the beta-1,3 glucans in the fungal cell wall. Fungicidal
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Examples of Echinocandins
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(caspofungin and micafungin)
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Use of Echinocandins
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Used for refractory Candida and Aspergillus infections
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MoA of Flucytosine:
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converted to 5-fluorouracil in fungal cells, which inhibits fungal DNA/RNA synthesis. Fungicidal
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use of Flucytosine
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Used for cryptococcal meningitis
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MoA Griseofulvin:
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blocks microtubule synthesis, thus stopping mitosis. Fungicidal or fungistatic, depending on concentration
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Use of Griseofulvin
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dermatophyte infections (generally ones resistant to topical treatment
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Tx for sporotrichosis infections
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potassium iodide (KI)
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