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19 Cards in this Set

  • Front
  • Back
98% of ulcers occur where?
upper duodenum
antral portion of ST

Gastric Ulcers are most related to

a) hypersecretion of acid
b) hyopesecretion of mucus
c) acid reflux
hyposecretion of mucus
duodenal ulcers or most related to

a) hypersecretion of acid
b) hyopesecretion of mucus
c) acid reflux
hypersecretion of acid
list the types of secreting cells
zymogenic/cheif- secrete pepsinogen

Parietal- secrete HCl to activate pepsinogen

Mucus Cells
goals on non-antibiotic pharmacological tx
neutralize acid- via weak base

prevent acid secretion of parietal cells

protect ST wall by supplementing mucus
Why is it a myth that milk acts as a good antacid?
bc its hi protein content actually increases gastric secretions and can make ulcers worse
list the mechanism of action of Antacids
reduce acid in GI
raise pH to decrease pepsin activity
strengthen mucosal barrier
increase sphincter tone

Al containing compounds are implicated in Hyperphosphatemia

HYPOphaspatemia- constipation

Mg containing compounds are implicated in Hypermagnesemia
T- diarrhea
intestinal obstruction is a likely adverse effect for which group - esp if taking Al products

a) children
b) women
c) elderly

a) simethicone (mulecon, oval)
b) protoprazol (protonix)
c) phenolphthlein (alopen)
simethicone (mulecon, oval)- defoam/disperse/prevent formation of mucus surrounded gas pockets in Gi
Do NOT mix with valium
cimetidine (tagamet) tx duodenal ulcers for max 8 weeks
Why are H2 receptor antagonists now available over the counter
ending proprietory period
H2 Antagonist that is ineffective in acute cases and must be used regularly

a) cimetidine (tagamet)
b) famotidine (pepcid)
c) ranitidine (zantac)
famotidine (pepcid)- may be used longer that 8 weeks but adverse effects are more likely

including: hallucination , diarrhea, constipation, NV
list the adverse effects of cimetidine (tagamet)
decrease bone marrow function
mental confusion, depression
dizzy, bradycardia
interstitial nephritis
lo sperm count, impotence
jaundice, rashes
H2 Antagonist w the lease adverse effects and best option for tx

a) cimetidine (tagamet)
b) famotidine (pepcid)
c) ranitidine (zantac)
ranitidine (zantac)

also prilosec ($$$) or protonix (Rx)
Acts as a physical barrier at site of ulcer

a) pantoprazole (protonix)
b) sucralfate (carafate)
c) Simethicone (mylicon)
sucralfate (carafate)

may cause dizzy, sleepy, constipation, NV, gastric discomfort
used for gastric and duodenal ulcers, and hypersecretory Zollinger-Ellison syndrome

a) ranitidine (zantac)
b) Alka Seltzer
c) famotidine (pepsid)
ranitidine (zantac)

also prilosec
Rx for GERD

a) Phenolphthein
b) Pantoprazole (protonix)
c) simethicone (mylicon)
pantoprazole (protonix)