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19 Cards in this Set
- Front
- Back
98% of ulcers occur where?
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upper duodenum
antral portion of ST |
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T/F
Gastric Ulcers are most related to a) hypersecretion of acid b) hyopesecretion of mucus c) acid reflux |
hyposecretion of mucus
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duodenal ulcers or most related to
a) hypersecretion of acid b) hyopesecretion of mucus c) acid reflux |
hypersecretion of acid
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list the types of secreting cells
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zymogenic/cheif- secrete pepsinogen
Parietal- secrete HCl to activate pepsinogen Mucus Cells |
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goals on non-antibiotic pharmacological tx
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neutralize acid- via weak base
prevent acid secretion of parietal cells protect ST wall by supplementing mucus |
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Why is it a myth that milk acts as a good antacid?
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bc its hi protein content actually increases gastric secretions and can make ulcers worse
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list the mechanism of action of Antacids
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reduce acid in GI
raise pH to decrease pepsin activity strengthen mucosal barrier increase sphincter tone |
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T/F
Al containing compounds are implicated in Hyperphosphatemia |
F
HYPOphaspatemia- constipation |
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T/F
Mg containing compounds are implicated in Hypermagnesemia |
T- diarrhea
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intestinal obstruction is a likely adverse effect for which group - esp if taking Al products
a) children b) women c) elderly |
elderly
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Antiflatulant
a) simethicone (mulecon, oval) b) protoprazol (protonix) c) phenolphthlein (alopen) |
simethicone (mulecon, oval)- defoam/disperse/prevent formation of mucus surrounded gas pockets in Gi
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Do NOT mix with valium
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cimetidine (tagamet) tx duodenal ulcers for max 8 weeks
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Why are H2 receptor antagonists now available over the counter
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ending proprietory period
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H2 Antagonist that is ineffective in acute cases and must be used regularly
a) cimetidine (tagamet) b) famotidine (pepcid) c) ranitidine (zantac) |
famotidine (pepcid)- may be used longer that 8 weeks but adverse effects are more likely
including: hallucination , diarrhea, constipation, NV |
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list the adverse effects of cimetidine (tagamet)
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decrease bone marrow function
mental confusion, depression dizzy, bradycardia interstitial nephritis lo sperm count, impotence jaundice, rashes gynecomastia |
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H2 Antagonist w the lease adverse effects and best option for tx
a) cimetidine (tagamet) b) famotidine (pepcid) c) ranitidine (zantac) |
ranitidine (zantac)
also prilosec ($$$) or protonix (Rx) |
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Acts as a physical barrier at site of ulcer
a) pantoprazole (protonix) b) sucralfate (carafate) c) Simethicone (mylicon) |
sucralfate (carafate)
may cause dizzy, sleepy, constipation, NV, gastric discomfort |
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used for gastric and duodenal ulcers, and hypersecretory Zollinger-Ellison syndrome
a) ranitidine (zantac) b) Alka Seltzer c) famotidine (pepsid) |
ranitidine (zantac)
also prilosec |
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Rx for GERD
a) Phenolphthein b) Pantoprazole (protonix) c) simethicone (mylicon) |
pantoprazole (protonix)
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