Pharmacology And Toxicology

Front 1

Define pharmacokinetics?

Back 1

Pharmacokinetics is what the body does to the drug

Front 2

Define Pharmacodynamics?

Back 2

Phamacodynamics is what the drug does to the body.

Front 3

Agonist and Antagonist?

Back 3

If a drug fits into a receptor, the receptor will either respond or be blocked

A drug that stimulates a receptor is an AGONIST and it mimics the effect of the natural mediator

A drug that blocks the effect of the natural mediator is an ANTAGONIST - an antagonist will prevent the natural chemical from acting on the receptor

Front 4

Pharmacology can be defined as?

Back 4

the science of drugs used to prevent, diagnose, and treat disease

Front 5

Explain the term bioavailability'

Back 5

Bioavailability – Definition:
“the degree to which a drug or other substance becomes available to the target tissue after administration

Front 6

Explain the term 'first past metabolism' and its significance to oral drug administration and oral overdose.

Back 6

A phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation
It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall

Front 7

Explain Therapeutic Threshold and Therapeutic Plateau

Back 7

Threshold – The minimum plasma concentration of a drug to give a therapeutic effect

Front 8

Explain Therapeutic Margin

Back 8

The plasma concentration of a drug between the therapeutic level and toxic level

Front 9

Maintenance Doses

Back 9

Drugs with a short duration of effect may require small incremental doses to maintain a therapeutic plasma level
These are called maintenance doses

Front 10

Half-Life

Back 10

The rate a drug is removed from the body