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11 Cards in this Set
- Front
- Back
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What is the MOA of aminoglycosides?
Describe their pharmacodynamics. |
Irreversible inhibition of the 30S subunit. This makes them bacteriosidal concentration dependent killers!
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What are the mechanisms of resistance to aminoglycosides
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Enzymes that modify the drugs (Tobra, Ama, Genta)
Mutations in the ribosome (streotomycin resistance) |
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What is the absorption and distribution profile of aminoglycosides?
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They are only give IV and they distribute into body fluids extremely well.
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What bugs do the aminoglycosides generally cover?
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G(+): Aerobes such as S. Aureus, S.Viridans, S. Pneumo (mainly genta)
G(-): A>T>G (so the opposite of G(+)) Entrobactericiae, does cover Pseudomonas Predominantly used in combination with a cell wall active antibiotic. |
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List 4 aminoglycosides
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Gentamicin
Streptomycin Tobramycin Amikacin |
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What is the efficacy of aminoglycosides on anerobes?
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Nothing!
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How do you dose aminoglycosides?
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On an individual basis, use TBW, and CrClearance to adjust. Draw peak and trough levels to adjust dosage
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What cell wall classes are combined with aminoglycosides?
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B-Lactams
Vancomycin |
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What aminoglycoside is given orally before abdominal surgery? Why?
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Neomycin, it reduces the number of G(-) in the flora to reduce infection risk.
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What are the side effects of aminoglycosides? What drugs make them more likely?
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Nephrotoxicity
Ototoxicity Vancomycin, Amphotericin B, CT Contrast |
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What is non-drug factors increase the side effects of aminoglycosides?
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Long high troughs, hypovolemia, renal failure, long term treatment
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