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17 Cards in this Set
- Front
- Back
Alcoholic type A?
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Later onset, less severe, more environmental, less dependence
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Alcoholic type B?
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Earlier onset, more severe dependence, paternal dependence, less environmental, associated personality disorder
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Neurobiology of Alcoholism?
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Release of DA(alcohol inhibits GABA) in VTA and NA. Mesolimbic involved in reward,
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Chronic alcohol use?
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Sensitizes system and causes a relative DA insufficiency
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Predisposes you to alcoholism?
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Lower Dopaminergic tone
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GABAergic system and Alcoholism?
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Agents that influence GABA-A receptors(benzos, barbiturates, antipsychotics) helps with alcohol control
Chronic use-decrease GABA-A receptors and increase sensitivity |
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Glutaminergic system and Alcoholism?
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Alcohol is NMDA receptor inhibitor, chronic use increases glutaminergic tone, eithdrawal causes hyperexitability
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Endogenous opioid system and alcoholism?
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Alcohol releases opioids, causes DA relaese in NA. Abnormal when family history of alcoholism
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5-HT system and alcohol?
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Type A respond better to SSRI's than type B. Use with comorbid psychiatric disorder
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Percent of risk of alcoholism is genetic?
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50%
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Genetic varient found in asians protecting them from alcoholism?
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ALDH, alcoholismis Acetaldahyde dehydrogenase
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Alcohol Withdrawal?
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Imbalance of GABA and glutamate causes seizures, delerium tremens,
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Disulfiram?
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Aldehyde dehydrogenase inhibitor, Small amounts of alcohol make you sick, SE: neuritis, hepatitis
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Oral Naltrexone?
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Mu opioid receptor antagonist, decrease DA release, decreases cravings, block pain meds
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Long-acting Injectable Naltrexone?
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lasts one month, less hepatotoxicity
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Acamprosate
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Glutamate receptor modulator(NMDA), normalizes glutaminergic hyperexitability, decreases cravings
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Combination therapy for alcoholism?
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Acamposate, Naltrexone
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