Pharmacology 50-51 Gi Drugs

Front 1

(P) OMEPRAZOLE

Back 1

PROTON-PUMP INHIBITOR

4:
GERD

MECH:
inhibits H+/K+ ATP-ase pump --> blocks gastric acid production

ADVERSES:
headA & D

* CYP-450 sys **

**longer duration in asians**

* no CRUSHING *

* 1 hour b4 meals *

Front 2

(P) RANITADINE

Back 2

H2 ANT

4:
ulcers

MECH:
inhibits gastric acid secretion

** DOES NOT HIT CYP-450 **

** must be given 2 hours apart from antacids **

** GIVE SLOW or you get hypOtn & arrhymias **

Front 3

(P) ALUMINUM HYDROXIDE (w/Mg hydroxide)

Back 3

ANTACIDS

4:
GERD

MECH:
raises pH in stomach & duodenum

ADVERSES:
D (frm Al), CONST (frm Mg) - can cancel out, but usually diarrhea wins

* give 2 hours b4 meals **

Front 4

(P) METROCLOPRAMIDE

Back 4

PROKINETIC (+ motion)

4:
diabetic gastroparesis (inadequete gastric squeezing)

MECH:
+ Fxs of ACh --> faster peristalsis/gastric emptying
(dopamine ANT --> same Fx)

INTRCT'N:
levodopa (dopa agonist)

* give 30 mins b4 @ meal **

Front 5

(P) PANCRELIPASE

Back 5

DIGESTIVE ENZYMES

4:
lack of pancreatic enzymes

MECH:
has AMYLASE, LIPASE, & PROTEASE

Front 6

(P) ONDANSETRON

Back 6

ANTI-EMETICS

4:
NAUSEA & VOMITING

MECH:
5-HT3 inhibitor - block sserontonin receptors
suppresses stim of CTZ & VC
(drugs classes that cause emesis: ANESTHESIA, OPIODS, CHEMO-)

* given 4 PONV (post-operative nausea & vomiting) as off-label use *

* give 30 mins b4 chemo *

* not a PREVENTATIVE 4 PONV - must give after they already abrf *

Front 7

(P) SIMETHICONE

Back 7

ANTI-FLATULANTS

4:
excess gas

MECH:
de-foaming breaks surface tension of gas bubbles

Front 8

(P) DIPHENOXYLATE HCl

Back 8

ANTI-DIARRHEALS

4:
diarhhea

MECH:
Prolongs intestinal transit time

* given w/ atropine to fight addiction *

Front 9

(P) MAGNESIUM HYDROXIDE (milk of Mg)

Back 9

ANTI-CONSTIPATION

4:
Constipation

MECH:
attracts H2O to intestinal lumen --> peristalsis

Front 10

(P) ALOSETRON

Back 10

4:
IBS

MECH:
blocks 5-HT3 (blocks serotonin type 3 receptors)

* follow w/ H2O *