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7 Cards in this Set

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Beta-lactam abx
Mechanism of action --> inhibitors of cell wall synthesis by interfering with final cross-linking steps during synthesis of the rigid peptidoglycan matrix
Resistance mechanisms to penicillin
1. beta lactamase
2. alteration in target PBP (penicillin binding proteins)
3. permeability barrier preventing penetration of abx to target
Natural penicillins
1. penicillin G
2. penicillin V
Antistaphylococcal penicillins
1. cloxacillin
2. dicloxacillin
3. methicillin
4. nafcillin
5. oxacillin
Extended spectrum penicillins
1. ampicillin
2. amoxicillin
3. amoxicillin + clavulanic acid (beta lactamase inhibitor)
4. ampicillin + subactam (beta lactamse inhibitor)
Antipseudomonal
1. Aziocillin
2. Carbenicillin
3. Mezloxillin
4. Piperacillin
5. Ticarcillin
6. Ticarcillin + clavulonic acid
7. Piperacillin + tazobactam
Penicillin activity
- gram (+) --> DOC for GAS, viridans
- gram (-)
- anaerobes
- active against treponema pallidum