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12 Cards in this Set
- Front
- Back
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Sympathomimetics: What is the difference between direct vs indirect acting adrenergic agonists?
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Direct acting agonists act directly on the adrenergic receptor. Indirect acting acting agonists do not bind to the receptors, but enhance the release of catecholamines that then bind to the receptors.
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Sympathomimectics: What is the difference between selective vs. nonselective acting adrenergic adrenergic agonists?
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Selective adrenergic agonists are selective to a specific receptor. A nonselective agonists affects multiple receptors.
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How are catecholamines synthesizes and released? What is the rate limiting step?
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Tyrosine -> (tyrosine hydroxylase)-> L Dopa -> Dopamine -> (Dopamine B hydroxylase) -> NE ->
1) a1 2) B1 3) B2 4) a2 = autoreceptor/(-) fb 5) reuptake, repackaged, broken down by MAO Rate limiting step = Tyrosine -> L Dopa |
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Nonselective Sympathomimetics:
Catecholamines Name Direct-Acting Adreno receptor Agonists |
DINE
Dopamine (Dose Dependent) Isopreoterenol Norepinephrine Epinephrine |
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Dopamine
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Dose Dependent
targets all receptors, but depends on dose D1/D2 = renal vasodilation B1 = cardiac stimulation a1 = vasoconstriction |
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Isoproterenol
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B1 = cardiac stimulation
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Norepinephrine
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a1=a2*
B1>B2* a1 = vasoconstriction B1 = cardiac stimulation good for sepsis & hypotensive crisis |
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Epinephrine
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a1 = vasoconstriction
B1 = cardiac stimulation B2 = vasodilation |
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Nonselective Sympathomimetics:
Catecholamines Name Indirect Acting Adrenoreceptor Agonists /Sympathomimetics |
MAME
Methamphetamines Amphetamines Methylphenidate (Ritaline), Pemoline (Cylert) Enhance release of catecholamines |
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Amphetamine
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Indirect acting sympathomimetic. Not acting as sympathomimetic & not acting as catecholamines but enhances release of catecholamines. doesn't agonize receptors.
Increases release of norepinephrine & dopamine |
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Methamphetamine
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Indirect acting Sympathomimetic. Not acting as sympathomimetic & not acting as catecholamines but enhances release of them. doesn't agonize receptors.
Similar to amphetamine (increases release of norepinephrine & dopamine) but higher CNS effects. |
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Methylphenidate, Pemoline
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Ritalin, Cylert
amphetamine variants for ADHD similar in action but therapeutic |
