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27 Cards in this Set
- Front
- Back
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what is pharmocokinetics
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Absorption
Distribution Metabolism Excretion |
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what is pharmaodynamics
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the chemical and physiologic changes that the drug causes
drug effect |
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what is bio-avalible
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is a subcategory of absorption and is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation,
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pharmacokinetic absorption
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the process involing movement of a drug moecules from the the site of entry into the circulating fulids
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what dose BBB stand for
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Blood Brain Barior anatomy of capillaries in the cns
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drug binding
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binding of a drug to a large molecule in the tissues or fluids, e.g. binding to protein in the blood, may affect the metabolism of the drug, especially its rate of excretion.
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what is First Pass Effect
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also known as first-pass metabolism or presystemic metabolism is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall
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Bioavailability
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is a subcategory of absorption and is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. as bioavailability must be considered when calculating dosages for non-intravenous routes of administration.
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name some of the bypass of the liver
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IM
Sub Q IV Supository |
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pharmacogenomics
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The study of how variations in the human genome affect the response to medications. permit drugs to be tailor-made for individuals and adapted to each person's own genetic makeup. Environment, diet, age, lifestyle
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what is Excretion
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process by which drugs and metabolites are removed from the body
Kidneys are most important route water-soluble drugs are eliminated |
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can you compare drugs like 5mg of one to the other
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no !!!
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Enteric coating
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is a barrier applied to oral medication that controls the location in the digestive system where it is absorbed. Enteric refers to the small intestine, therefore enteric coatings prevent release of medication before it reaches the small intestine.
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what is LD50
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is the dose required to kill half the members of a tested population after a specified test duration
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what is ED50
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is the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it.
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Drug-Food Interactions
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Similar to drug-drug interactions
Food can alter the absorption or metabolism of medications Diets can alter the bacterial flora of the intestine and may affect the metabolism of certain drugs |
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what is Idiosyncratic Reactions
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Fever
Blood dyscrasias Cardiovascular effects Change in mental status |
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what is tough level
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residual amount right before next delivery (10-15 minutes prior). is the lowest level that a medicine is present in the body
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what is tough level
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residual amount right before next delivery (10-15 minutes prior). is the lowest level that a medicine is present in the body
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what is Toxicology
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science of harmful effects
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what is Pharmacotherapeutics
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clinicalindications, prevention, diagnosis and treatment of a living organism
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what is formularies
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every hospital has a {X} amout of drug in the hospital they do not have every drug in the books
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exsplane what Schedule of Controlled Drugs
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It has 5 stages ..stage 1 is the most abused. stage 5 is like otc drug the ones in the middle is are mostly given to PT
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what Drug transfer to fetus
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Teratogenic, mutagenic, carcinogenic
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what is Mutagen
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a substance that causes mutation, i.e. that causes changes in genes.
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what is Teratogen
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Substance that deforms the fetus in the womb and so induces birth defects
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what is Carcinogen
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Substance that deforms the fetus in the womb and so induces birth defects.
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