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19 Cards in this Set

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Why are they called Dissociative Anesthetics?
Called “dissociative” because humans appear to feel dissociated from and unaware of environment but not asleep
MOA of Dissociative Anesthetics
Noncompetitive antagonist at N-methyl-D-aspartate (NMDA) receptors
Besides NMDA receptors, what other receptors do dissociative anesthetics have an effect?
Have some additional effect at opioid, monoaminergic, & muscarinic receptors and voltage-gated calcium channels
Do dissociative anesthetics cause analgesia?
YES they cause analgesia, likely through effect at mu and kappa opioid receptors

* Analgesia greater for somatic pain than visceral
2 major effects of dissociative anesthetics?
Produce dose related unconsciousness and analgesia
What are the 3 dissociative anesthetics discussed in class?
1.Ketamine (Special K)
2.Tiletamine
3. Phencyclidine (PCP)
MOA of Ketamine
NMDA Receptor antagonist
Which dissociative anesthetic is the least potent?
Ketamine
Is Ketamine a scheduled drug?
YES-Schedule III controlled drug
What 4 effects does Ketamine have on the CNS?
* Hallucinations
* Dissociate CNS from rest of body
* Increase CNS blood flow
* Increase intraocular pressure
What effects does Ketamine have on the cardiovascular system?
Increases HR/BP (stimulate symp NS)
What effects does Ketamine have on the respiratory system?
*** Apneustic pattern of breathing (holding breath); intubate!

* Increased secretions/salivation

* Can give w/atropine/glycopyrrolate to dec secretion side effects
What effects does Ketamine have on the musculoskeletal system?
tremors/myoclonus
What effects does Ketamine have on the eyes?
eyes remain open due to increased intraocular pressure
What contraindications are associated with Ketamine?
Do not use in patients with head trauma, cardio dz, liver/kidney dz (prolongs effects b/c not eliminated)
First dissociative anesthetic used in vet med?
Phencyclidine (PCP)
WHich dissociative anesthetic is the most potent?
Phencyclidine (PCP)
What drug is Tiletamine usually combined with?
Combination with Zolazepam = Telazol

** Metabolozed as 2 diff drugs with different half lives
Is Tiletamine a scheduled drug?
YES! Schedule III controlled drug