Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
19 Cards in this Set
- Front
- Back
|
Why are they called Dissociative Anesthetics?
|
Called “dissociative” because humans appear to feel dissociated from and unaware of environment but not asleep
|
|
|
MOA of Dissociative Anesthetics
|
Noncompetitive antagonist at N-methyl-D-aspartate (NMDA) receptors
|
|
|
Besides NMDA receptors, what other receptors do dissociative anesthetics have an effect?
|
Have some additional effect at opioid, monoaminergic, & muscarinic receptors and voltage-gated calcium channels
|
|
|
Do dissociative anesthetics cause analgesia?
|
YES they cause analgesia, likely through effect at mu and kappa opioid receptors
* Analgesia greater for somatic pain than visceral |
|
|
2 major effects of dissociative anesthetics?
|
Produce dose related unconsciousness and analgesia
|
|
|
What are the 3 dissociative anesthetics discussed in class?
|
1.Ketamine (Special K)
2.Tiletamine 3. Phencyclidine (PCP) |
|
|
MOA of Ketamine
|
NMDA Receptor antagonist
|
|
|
Which dissociative anesthetic is the least potent?
|
Ketamine
|
|
|
Is Ketamine a scheduled drug?
|
YES-Schedule III controlled drug
|
|
|
What 4 effects does Ketamine have on the CNS?
|
* Hallucinations
* Dissociate CNS from rest of body * Increase CNS blood flow * Increase intraocular pressure |
|
|
What effects does Ketamine have on the cardiovascular system?
|
Increases HR/BP (stimulate symp NS)
|
|
|
What effects does Ketamine have on the respiratory system?
|
*** Apneustic pattern of breathing (holding breath); intubate!
* Increased secretions/salivation * Can give w/atropine/glycopyrrolate to dec secretion side effects |
|
|
What effects does Ketamine have on the musculoskeletal system?
|
tremors/myoclonus
|
|
|
What effects does Ketamine have on the eyes?
|
eyes remain open due to increased intraocular pressure
|
|
|
What contraindications are associated with Ketamine?
|
Do not use in patients with head trauma, cardio dz, liver/kidney dz (prolongs effects b/c not eliminated)
|
|
|
First dissociative anesthetic used in vet med?
|
Phencyclidine (PCP)
|
|
|
WHich dissociative anesthetic is the most potent?
|
Phencyclidine (PCP)
|
|
|
What drug is Tiletamine usually combined with?
|
Combination with Zolazepam = Telazol
** Metabolozed as 2 diff drugs with different half lives |
|
|
Is Tiletamine a scheduled drug?
|
YES! Schedule III controlled drug
|
