Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
What is the mechanism of a Cholinergic Antagonist?
|
Competitively prevent action of acetylcholine at muscarinic and nicotinic receptors
|
|
|
What are the 3 cholinergic antagonists discussed in class?
|
* Atropine
* Glycopyrrolate * N-butylscopolammonium bromide |
|
|
What type of drug is Atropine?
|
Antimuscarinic cholinergic antagonist (High doses may block nicotinic receptors)
(competitively inhibits acetylcholine at post-ganglionic parasympathetic sites) |
|
|
Can atropine cross into the CNS?
|
YES:Can cross into CNS
|
|
|
What does the use of Atropine do to salivary and bronchial secretions?
|
Inhibition of salivary and bronchial secretions
|
|
|
What does the use of Atropine do to sweating?
|
Inhibition of sweating (except horses)
|
|
|
What does the use of Atropine do to the pupils?
|
Dilation of the eye
|
|
|
What does the use of Atropine do to heart rate?
|
Increased heart rate
|
|
|
What does the use of Atropine do to GI and urinary tract motility?
|
Decrease GI and urinary tract motility (high doses)
|
|
|
What does the use of Atropine do to bladder tone?
|
Decreased bladder tone
|
|
|
What toxic poisoning can Atropine be used for?
|
Can resolve clinical signs of organophosphate poisoning, but doesn’t solve problem
|
|
|
What type of drug is Glycopyrrolate?
|
Antimuscarinic Cholinergic Antagonist (High doses may block nicotinic receptors)
(competitively inhibits acetylcholine at post-ganglionic parasympathetic sites) |
|
|
What can the use of Glycopyrrolate do to salivary and bronchial secretions?
|
Inhibition of salivary and bronchial secretions
|
|
|
What can the use of Glycopyrrolate do to sweating?
|
Inhibition of sweating
|
|
|
What can the use of Glycopyrrolate do to the pupils?
|
Dilation of the eye
|
|
|
What can the use of Glycopyrrolate do to heart rate?
|
Increased heart rate
|
|
|
What can the high doses of Glycopyrrolate do to GI and urinary tract motility?
|
Decrease GI and urinary tract motility (high doses)
|
|
|
What type of drug is N-butylscopolammonium bromide?
|
Antimuscarinic Cholinergic Antagonist
(competitively inhibits acetylcholine on smooth muscle) |
|
|
What does the use of N-butylscopolammonium bromide do to gastrointestinal peristalsis and rectal pressure?
|
Reduces gastrointestinal peristalsis and rectal pressure
|
|
|
What is N-butylscopolammonium bromide commonly used for?
|
Used for colic
|
