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5 Cards in this Set
- Front
- Back
Anti-inflammatory Agents Salicylates ASPIRIN Choline magnesium trisalicylate + Aspirin --> ok w/children Balzalazide--> Ulcerative colitis |
Action: Inhibits synthesis of prostaglandins I: Mild to moderate pain, fever, inflammation r/t RA, OA CI: Blood disorders. Impaired Kidney. Never use in children w/ Influenza or Chicken pox -> Reye's Syndrome (inflammation of brain and liver - confusion, seizures, LOC) AE: Tinnitus, Occult blood loss, acidosis D2D: Oral anticoagulants NC: monitor for ototoxicity. d/c before sx. Dysmenorrhea care: 2days prior and d/c if heavy bleeding |
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NSAIDS and related agents IBUPROFEN |
A: inhibits prostaglandins synthesis l/t anti-inflammatory effect. Rest Same as Acetaminophen |
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NSAID related agent ACETAMINOPHEN antidote (acetylcysteine) |
A: Acts directly on the hypothalamus (vasodilation/sweating) I: mild to moderate pain d/t RA and OA, fever, cold, flu, dysmenorrhea, prophylactic for in children receiving DPT vaccine CI: Pt allergic to salicylates, tartrazine (yellow #5),sulfonamides AE:Headache, hemolytic anemia, BMsuppression, HEPATOTOXICITY (od) D2D: Oral anticoagulants Older adults AVOID: naproxen, ketorolac, ketoprofen |
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Anti-arthritis Agents Gold compounds Do not repair, only prevents future damage AURANOFIN |
Chrysotherapy: tx with gold salts A: reabsorbed by macrophages--> no phagocytosis l/t decreased tissue destruction I: RA, Juvenile RA, CI: Diabetes, CHF, renal/hepatic Impairment AE: BM SUppression, stomatitis, glossitis, dermatitis D2D: Penicillamine, antimalarials, cytotoxic drugs or immunosuppressive agents NC: placenta/breastmilk, Use contraception. ok w/children |
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Disease Modifying Anti-Rheumatic Drugs ANAKINRA ETANERCEPT (ok for children) LEFLUNOMIDE PENCILLAMINE Antineoplastic drug METHOTRAXATE MONOCLONAL ANTIBODIES INFLIXIMAB ADALIMUMAB Used to decrease pain in arthritic joints - HYALURONIDASE DERIVATIVE (injected into joint) |
A: Aggresively alters the process of inflammation Used early in dx before damage to joints has occurred I: Relief of S&S of RA and OA, mild to moderate pain, dysmenorrhea, fever AE: alter ability to initiate inflammation, infection BMSuppresion SE: Infection, leukopenia, thrombocytopenia, LFT abnormalities, renal disease |
