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9 Cards in this Set

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What is Cytochrome P-450?
What types of drugs are metabolized by Cytochrome P-450?
Cytochrome P 450 is a protein enzyme. P-450 3A4 is the most abundant.
Metabolizes Benzodiazepines, Opiods, Local anesthetics, and immunosuppressants.
If you inhibit the Cytochrome P-450 enzyme, what types of drugs will not be metabolized?
Benzodiazepines, Opiods, Local anesthetics, immunosuppressants
What drugs have the ability to stimulate Enzyme Induction?
Carbamazepine, Cigarettes, Rifampin, Alcohol, Phenytoin, Phenobarbital
<CCRAPP>
What drugs are Enzyme INHIBITORS?
Protease inhibitors, Alcohol (acute), Cimetidine, Erythromycin, Nefazodone, Valproic Acid, Fluoxetine, Amiodarone, Diltiazem

<PACENVFAD>
Factors that effect Volume of Distribution and Clearance?
Hepatic disease, kidney disease, metabolism, Age
CENTRAL Compartment Includes?

PERIPHERAL comparment
Intravascular fluid, lungs, heart, brain, kidneys, liver

Peripheral: MUSCLES & FAT
define hyperactive, hypersensitivity, hyporeactive, tolerance, tachyphylaxis
HYPERACTIVE: unusually low doses produce desired effect

Hypersensitive: Term used to describe patients that are allergic to a drug

Hyporeactive: patients that require unusually high doses to evoke a desired effect

Tolerance: Describes hyporeactivity that is acquired from chronic exposure to a drug

Tachyphylaxis: is tolerance that develops after a few doses or short period of time
HOFFMAN elimination?
metabolism that occurs in the PLASMA. PH & Temperature dependent
ex: Atracurium, Cisatracurium (AC)

Atracurium and Cisatracurium both attain maximum effect in < 2 min after rapid IV injection.
What drugs undergo ZERO order kinetics?


Halothane "hepatitis"---what is it?
Alcohol, Aspirin, Dilatin, & Phenytoin


when Halogenated volatile anesthetics are broken down, the intermediates can lead to change in live cell formation---->no longer recognized as "self"...enzymes attack the deformed liver cells (HEPATITIS)