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28 Cards in this Set
- Front
- Back
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PGG2 is a component of what pathway?
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COX
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PGH2 is a component of what pathway?
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COX
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leukotrienes and lipoxins are the end products of what pathway?
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lipoxygenase
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prostaglandins are the end products of what pathways?
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COX
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prostacyclins (PGI2) are the end products of what pathways?
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COX
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thromboxane is the end product of what pathway?
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COX
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what is the basic enzyme that will activate the formation of arachadonic acid?
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phospholipid A2
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what COX isoform maintains good prostaglandins
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COX-1
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what cox isoform catalyzes the synthesis of PGE2 and PGI2 that have cytoprotective actions?
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cox-1
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what cox isoform maintains renal function via vasomotor tone?
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cox-1
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inflammation is associated with upregulaion of what?
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cox-2
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what metastatic process requires cox-2?
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angiogenesis
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what function is PGE2 induced in?
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renal function
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what does TXA-2 do?
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platelet formation
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what does PGI-2 do?
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gastric protection
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what is the most important leukotriene?
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LTB4
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what does LTB4 do for neutrophils?
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causes neutrophil adherence to vascular endothelial cells and enhances the rate of migration of neutrophils in extra-vascular tissues
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what does LTB4 elicit in leukocytes?
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chemotaxis, adherence, and aggregation
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what inhibits lipoxygenase enzyme?
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ziluton
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what is the main bronchoconstrictor in asthma?
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LTC4
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what inhibits platelet aggregation?
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prostacyclins
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what is the suffix for leukotriene antagonists?
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-leucasts
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what are the most potent anti-inflammatory agents?
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corticosteroids
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how do corticosteroids work?
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inhibit phospholipase A2 so the top of the pathway is inhibited and anything below are history
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why are NSAIDs used to close the DA?
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PGE1 plays a role in maintaining a patent DA
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what is carboprost?
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PGF2 analog
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what is misoprostol?
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a PGE2 analog
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what is misoprostol used for?
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prevention of peptic ulcers in patients on high doses of NSAIDs
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