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4 Cards in this Set
- Front
- Back
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What is the volume of distribution (Vd)?
What is the equation? When would drugs carried by proteins have an altered Vd? |
relates the amount of drug in a body to the plasma concentration.
Vd = (amount of drug in the body)/(plasma drug concentration) Vd of drugs carried by proteins is altered by kidney/liver dz. |
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How do drugs distribute in the body with a:
Low Vd (4-8 L)? Medium Vd? High Vd (more than body weight)? |
Low = in blood
medium = in extracellular space or body water high = into ALL tissues |
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Clearance - what does it relate and what is the equation?
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rate of elimination to plasm concentration
CL = rate of elimination of drug/plasma drug concentration CL = Vd * Ke (elimination constant) |
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Half-life (t1/2)
What is it and the equation Is it a property of zero order or 1st order elimination? How long does it take to reach steady state if a drug is infused at a constant state? |
Half life = the time it takes to change the amount of drug in the body by 1/2 during elimination (or constant infusion).
t 1/2 = (0.7 *Vd)/ CL It takes 4-5 half lives to reach steady state, at 4 t1/2 ~ 93.75% |
